摘要
皮肤途径对于输送治疗各种疾病的药物很有吸引力。然而,角质层(SC)是妨碍皮肤渗透的有效屏障。在这种情况下,脂质体作为改善局部递送治疗剂的潜在载体出现。在这篇综述中,我们旨在讨论载药脂质体局部给药的关键方面。已显示磷脂类型和相变温度影响脂质体局部递送。表面电荷的影响取决于药物和成分而受到相当大的变化。另外,表面活性剂和溶剂等存在渗透增强组分的改性囊泡已被证明具有相当的效果。这些脂质体包括:Transfersomes,Niosomes,Ethosomes,Transethosomes,Invasomes,包被的脂质体,含有囊泡的渗透促进剂(PEV),脂肪酸囊泡,古细菌体和Marinosomes。此外,在脂质体表面添加聚合物涂层可影响皮肤递送。递送机制包括完整的囊泡皮肤渗透,游离药物扩散,增强渗透,囊泡吸附到SC和/或与SC融合,跨附件穿透等等。最后,包括痤疮,黄褐斑,皮肤老化,真菌感染和皮肤癌在内的几种皮肤病症已经从脂质体局部递送药物中受益,并具有有希望的体外和体内结果。然而,尽管存在一些临床试验,但仍需进行更多研究以探索脂质体在皮肤病领域的潜力
关键词: 脂质体,皮肤,局部递送,药物递送,皮肤病学,包封。
Current Medicinal Chemistry
Title:Recent Advances and Perspectives in Liposomes for Cutaneous Drug Delivery
Volume: 25 Issue: 5
关键词: 脂质体,皮肤,局部递送,药物递送,皮肤病学,包封。
摘要: The cutaneous route is attractive for the delivery of drugs in the treatment of a wide variety of diseases. However the stratum corneum (SC) is an effective barrier that hampers skin penetration. Within this context, liposomes emerge as a potential carrier for improving topical delivery of therapeutic agents. In this review, we aimed to discuss key aspects for the topical delivery by drug-loaded liposomes. Phospholipid type and phase transition temperature have been shown to affect liposomal topical delivery. The effect of surface charge is subject to considerable variation depending on drug and composition. In addition, modified vesicles with the presence of components for permeation enhancement, such as surfactants and solvents, have been shown to have a considerable effect. These liposomes include: Transfersomes, Niosomes, Ethosomes, Transethosomes, Invasomes, coated liposomes, penetration enhancer containing vesicles (PEVs), fatty acids vesicles, Archaeosomes and Marinosomes. Furthermore, adding polymeric coating onto liposome surface could influence cutaneous delivery. Mechanisms of delivery include intact vesicular skin penetration, free drug diffusion, permeation enhancement, vesicle adsorption to and/or fusion with the SC, trans-appendageal penetration, among others. Finally, several skin conditions, including acne, melasma, skin aging, fungal infections and skin cancer, have benefited from liposomal topical delivery of drugs, with promising in vitro and in vivo results. However, despite the existence of some clinical trials, more studies are needed to be conducted in order to explore the potential of liposomes in the dermatological field.
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Cite this article as:
Recent Advances and Perspectives in Liposomes for Cutaneous Drug Delivery, Current Medicinal Chemistry 2018; 25 (5) . https://dx.doi.org/10.2174/0929867324666171009120154
DOI https://dx.doi.org/10.2174/0929867324666171009120154 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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