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Review Article

2型糖尿病患者的血小板氧化应激及其与心血管疾病的关系

卷 26, 期 22, 2019

页: [4145 - 4165] 页: 21

弟呕挨: 10.2174/0929867324666171005114456

价格: $65

摘要

增强的血小板活化和血栓形成与各种心血管疾病（CVD）相关。在其他机制中，氧化应激似乎在血小板过度活跃中起关键作用。实际上，在受到生理激动剂刺激后，人体血小板会生成并释放多种类型的活性氧（ROS），例如O2-，H2O2或OH-，从而通过各种信号途径进一步放大血小板活化反应，包括形成异前列腺素，Ca2 +动员和NO灭活。此外，过多的血小板ROS生成，来自环境的自由基的掺入和/或抗氧化剂的消耗诱导了促氧化剂，促炎和血小板过度凝集作用，从而导致心血管事件的发生。在这里，我们回顾了有关氧化应激对血小板信号通路的影响及其在CVD（如2型糖尿病）中的意义的当前知识。我们还总结了包括在蔬菜，水果和草药中的天然抗氧化剂在通过氧化应激介导的机制降低血小板功能中的作用。

关键词: 血小板，活性氧，心血管疾病，糖尿病，抗氧化剂，信号转导。

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