Abstract
Paraoxonase-1 is a lactonase and an esterase and it plays a protective role in toxicity as well as in diseases involving oxidative stress. Recently, insights into how it may be modulated by environmental factors have acquired clinical relevance. This article reviews the state-of-the-art evidence regarding PON1 modulation by pharmacological products as well as nutritional and lifestyle factors.
Keywords: Apolipoprotein A-I, fibrates, high-density lipoproteins, lipid peroxidation, nutrition, paraoxonase-1, rosiglitazone, statins
Mini-Reviews in Medicinal Chemistry
Title: Pharmacological and Lifestyle Factors Modulating Serum Paraoxonase-1 Activity
Volume: 9 Issue: 8
Author(s): Jordi Camps, Judit Marsillach and Jorge Joven
Affiliation:
Keywords: Apolipoprotein A-I, fibrates, high-density lipoproteins, lipid peroxidation, nutrition, paraoxonase-1, rosiglitazone, statins
Abstract: Paraoxonase-1 is a lactonase and an esterase and it plays a protective role in toxicity as well as in diseases involving oxidative stress. Recently, insights into how it may be modulated by environmental factors have acquired clinical relevance. This article reviews the state-of-the-art evidence regarding PON1 modulation by pharmacological products as well as nutritional and lifestyle factors.
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Cite this article as:
Camps Jordi, Marsillach Judit and Joven Jorge, Pharmacological and Lifestyle Factors Modulating Serum Paraoxonase-1 Activity, Mini-Reviews in Medicinal Chemistry 2009; 9 (8) . https://dx.doi.org/10.2174/138955709788681591
DOI https://dx.doi.org/10.2174/138955709788681591 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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