Abstract
As a group, nitric oxide synthase (NOS) isoforms are localized to a wide variety of tissues. Understanding the role of NOS in reproductive physiology was facilitated by the introduction of genetically engineered mice. Specifically, “knock-out” mice with targeted disruptions in neuronal NOS, endothelial NOS and inducible NOS have been made. These models have been useful in addressing the of role of nitric oxide in areas of reproductive biology that include: hypothalamic-pituitary-ovarian axis, mating behavior, maternal blood pressure regulation and fetal development. Despite several promising observations using “knock-out” mouse models, one must exercise caution in interpreting data from individual experiments. Very often the need to draw on two mouse strains to generate the founder NOS deficient line, purity of the strain used for observing phenotypes (presence or absence of backcrossing to achieve a pure strain), and the strain used for comparison purposes (control strains are often not identical in their genetic make-up to the deficient line) make wide spread applicability of results open to criticism.
Keywords: nitric oxide, no, nos, nitric oxide synthase, nos isoforms, neuronal nos
Current Pharmaceutical Design
Title: Mouse Models and the Role of Nitric Oxide in Reproduction
Volume: 9 Issue: 5
Author(s): Anthony R. Gregg
Affiliation:
Keywords: nitric oxide, no, nos, nitric oxide synthase, nos isoforms, neuronal nos
Abstract: As a group, nitric oxide synthase (NOS) isoforms are localized to a wide variety of tissues. Understanding the role of NOS in reproductive physiology was facilitated by the introduction of genetically engineered mice. Specifically, “knock-out” mice with targeted disruptions in neuronal NOS, endothelial NOS and inducible NOS have been made. These models have been useful in addressing the of role of nitric oxide in areas of reproductive biology that include: hypothalamic-pituitary-ovarian axis, mating behavior, maternal blood pressure regulation and fetal development. Despite several promising observations using “knock-out” mouse models, one must exercise caution in interpreting data from individual experiments. Very often the need to draw on two mouse strains to generate the founder NOS deficient line, purity of the strain used for observing phenotypes (presence or absence of backcrossing to achieve a pure strain), and the strain used for comparison purposes (control strains are often not identical in their genetic make-up to the deficient line) make wide spread applicability of results open to criticism.
Export Options
About this article
Cite this article as:
Gregg R. Anthony, Mouse Models and the Role of Nitric Oxide in Reproduction, Current Pharmaceutical Design 2003; 9 (5) . https://dx.doi.org/10.2174/1381612033391829
DOI https://dx.doi.org/10.2174/1381612033391829 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Rheumatoid Nodulosis in a Patient with Lupus Erythematosus: Case Report and Review
Current Rheumatology Reviews Antioxidant Properties and Associated Mechanisms of Salicylates
Current Medicinal Chemistry Markers of Arrhythmogenic Risk in Hypertensive Subjects
Current Pharmaceutical Design RAAS Inhibition and Cardiorenal Syndrome
Current Hypertension Reviews Glucocorticoids and the Cardiovascular System: State of the Art
Current Pharmaceutical Design Optimized High-Yield Purification of Obesity-Associated Melanocortin 4 Receptor
Protein & Peptide Letters High-risk Pregnancy and Perinatal Outcome: An Observational Study
Current Women`s Health Reviews Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis
Current Proteomics The Association between Metabolic Syndrome and Serum Levels of Adiponectin and High Sensitive C Reactive Protein in Gorgan
Endocrine, Metabolic & Immune Disorders - Drug Targets Development and Validation of a Simple LC-UV Method to Assay Doxazosin in Polymeric Nanocapsules and Tablets
Current Pharmaceutical Analysis Research/Review: Insights into the Mutation-Induced Dysfunction of Arachidonic Acid Metabolism from Modeling of Human CYP2J2
Current Drug Metabolism Antithrombotic Options for Atrial Fibrillation in 2012
Cardiovascular & Hematological Disorders-Drug Targets Mineralocorticoid Receptor-Associated Hypertension and Target Organ Damage: Clinical Relevance for Resistant Hypertension in End Stage Renal Disease
Current Hypertension Reviews Inflammatory Mechanisms and Redox Status in Periodontal and Cardiometabolic Diseases: Effects of Adjunctive Nutritional Antioxidants and Statins
Infectious Disorders - Drug Targets Pulmonary Vascular Function in Insulin Resistance and Diabetes
Current Vascular Pharmacology Roles of IL-6-gp130 Signaling in Vascular Inflammation
Current Cardiology Reviews Effects of Thiazolidinediones on Coronary Artery Disease: Review
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Natural Products in Regression and Slowing of Progression of Atherosclerosis
Current Pharmaceutical Biotechnology COVID-19 Severity: Lung-Heart Interplay
Current Cardiology Reviews Intravitreal Triamcinolone for the Treatment of Diabetic Macular Edema
Current Diabetes Reviews