摘要
角膜上皮疾病在现代眼科学中占有一席之地。角膜上皮的缺陷通常伴有视力模糊，畏光和撕裂。由于角膜是生物体中密度最高的受神经支配的组织，其破坏导致严重疼痛综合征的发展。轻度角膜糜烂通常会快速自发恢复。由于各种病理原因抑制角膜伤口愈合导致严重复发性糜烂和持续性角膜缺陷的发展。这些病理事件又可导致角膜瘢痕，浑浊和角膜溃疡，并最终导致永久性视力障碍。通常涉及炎症，神经营养和全身因素的潜在角膜疾病的病因应该考虑用于治疗这些缺陷。因此，研究重点已转移到建立基于蛋白质和肽的治疗方法。由于不同的作用机制，基于蛋白质的药物可以参与角膜表面的保护，模拟泪液成分，刺激角膜伤口愈合，角膜神经支配的再生，抑制氧化应激，炎症和新血管形成。活性成分可以是天然存在的（血液或泪液衍生的）或从头创建并优化以获得所需的活性水平。如果局部给药，这些药物的特征在于低毒性和没有全身副作用，因为它们对血流的吸收低。本综述总结了目前处于临床前开发或临床试验中测试或批准用于医学用途的角膜上皮缺损治疗的基于蛋白质的药物的现有数据。
关键词: 治疗性蛋白质，角膜缺陷，干眼症，角膜伤口愈合，神经变性，氧化应激，炎症，新血管形成。
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Mimetogen Pharmaceuticals Announces Topline Results of Its Second Clinical Study with MIM-D3 for the Treatment of Dry Eye Syndrome. . http://www.mimetogen.com/news- publications/press-releases/51-mimetogen-pharmaceuticals- announces-topline-results-of-its-second-clinical-study-with- mim-d3-for-the-treatment-of-dry-eye-syndrome.html
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