摘要
近年来,由于正电子发射断层扫描(PET)的扩展潜力,人们对分子成像越来越感兴趣。PET成像的作用,最初仅限于onc由于新型放射性药物的发展和混合成像技术的实施,PET扫描与计算机断层成像技术相结合,使其不断扩展。[CT]或磁共振成像[MRI],以提高空间分辨率。 早期的临床前研究表明,18F-fdg PET可以检测神经炎症;针对更具体的炎症相关分子的新的放射性药物正在此区域移动。小贝。神经系统损害是各种系统性自身免疫性疾病的一个明显特征,即系统性红斑狼疮(SLE)或白塞氏病(BD)。虽然MRI大部分被认为是金标准成像技术,用于检测中枢神经系统(CNS)与这些疾病的关系。一些病人抱怨有神经精神症状[头痛,癫痫,焦虑症]。在没有任何明显的MRI表现的情况下,诊断主要依赖于临床检查和疾病过程与医源性或反应性的作用。e表格是可疑的。 本文旨在探讨PET显像在中枢神经系统参与系统性风湿性疾病中的作用及其研究进展。此外,我们还探讨了新出现的放射线的潜在作用。药物及其在中枢神经系统自身免疫性疾病诊断中的应用。
关键词: 正电子发射断层扫描,脑,中枢神经系统,系统性红斑狼疮,血管炎,白塞病。
Current Medicinal Chemistry
Title:Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives
Volume: 25 Issue: 26
关键词: 正电子发射断层扫描,脑,中枢神经系统,系统性红斑狼疮,血管炎,白塞病。
摘要: In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography [PET]. The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography [CT] or magnetic resonance imaging[MRI] in order to improve spatial resolution.
Early preclinical studies suggested that 18F–FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction. Neurological involvement is a distinct feature of various systemic autoimmune diseases, i.e. Systemic Lupus Erythematosus [SLE] or Behcet’s disease [BD]. Although MRI is largely considered the gold-standard imaging technique for the detection of Central Nervous System [CNS] involvement in these disorders. Several patients complain of neuropsychiatric symptoms [headache, epilepsy, anxiety or depression] in the absence of any significant MRI finding; in such patients the diagnosis relies mainly on clinical examination and often the role of the disease process versus iatrogenic or reactive forms is doubtful.
The aim of this review is to explore the state-of-the-art for the role of PET imaging in CNS involvement in systemic rheumatic diseases. In addition, we explore the potential role of emerging radiopharmaceutical and their possible application in aiding the diagnosis of CNS involvement in systemic autoimmune diseases.
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Cite this article as:
Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives, Current Medicinal Chemistry 2018; 25 (26) . https://dx.doi.org/10.2174/0929867324666170523144402
DOI https://dx.doi.org/10.2174/0929867324666170523144402 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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