Abstract
Components of the extracellular environment can be transported into cells by molecular mechanisms collectively termed endocytosis. Cells typically use a multitude of such internalization pathways. These endocytic transport pathways have a wide range of implications for physiological regulation as well as pathological processes. Many infectious diseases, for example, involve internalization of the pathogen into the cell as part of the infection process. Selective interference with the endocytic transport of a microbe, thus, represents a therapeutic strategy that may prevent infections or decrease the rate of their progression. Herein, we provide a brief review of strategies for discovery of novel anti-infection drugs and their pharmacological implications.
Keywords: Drug discovery, endocytic transport, high-throughput screening, infection, pathogens.
Graphical Abstract
Infectious Disorders - Drug Targets
Title:Endocytic Transport as a Drug Target in Infectious Diseases
Volume: 18 Issue: 1
Author(s): Shaun P. Wong and Amandio Vieira*
Affiliation:
- Metabolic Research Laboratory, Department of Biomedical Physiology BPK, Simon Fraser University, Burnaby, BC, V5A 1S6,Canada
Keywords: Drug discovery, endocytic transport, high-throughput screening, infection, pathogens.
Abstract: Components of the extracellular environment can be transported into cells by molecular mechanisms collectively termed endocytosis. Cells typically use a multitude of such internalization pathways. These endocytic transport pathways have a wide range of implications for physiological regulation as well as pathological processes. Many infectious diseases, for example, involve internalization of the pathogen into the cell as part of the infection process. Selective interference with the endocytic transport of a microbe, thus, represents a therapeutic strategy that may prevent infections or decrease the rate of their progression. Herein, we provide a brief review of strategies for discovery of novel anti-infection drugs and their pharmacological implications.
Export Options
About this article
Cite this article as:
Wong P. Shaun and Vieira Amandio *, Endocytic Transport as a Drug Target in Infectious Diseases, Infectious Disorders - Drug Targets 2018; 18 (1) . https://dx.doi.org/10.2174/1871526517666170502154908
DOI https://dx.doi.org/10.2174/1871526517666170502154908 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
An Update on Drug Interactions with the Herbal Medicine Ginkgo biloba
Current Drug Metabolism First Episode Psychosis, Substance Abuse and Prognosis: A Systematic Review
Current Psychiatry Reviews Health Service Utilization and Costs of Depressive Symptoms in Late Life - A Systematic Review
Current Pharmaceutical Design Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review
Current Drug Targets Exploring the Chemical Space of P-Glycoprotein Interacting Compounds
Mini-Reviews in Medicinal Chemistry Species Scaling and Extrapolation
Current Drug Metabolism Stimulated CB1 Cannabinoid Receptor Inducing Ischemic Tolerance and Protecting Neuron from Cerebral Ischemia
Central Nervous System Agents in Medicinal Chemistry Increase Signaling of Wnt/β-Catenin Pathway and Presence of Apoptosis in Cerebellum of Kindled Rats
CNS & Neurological Disorders - Drug Targets A Disposable, Highly Sensitive Biosensing System: Determination of Haptoglobin as a Significant Acute Phase Biomarker
Current Analytical Chemistry Overcoming Cell Death and Tau Phosphorylation Mediated by PI3KInhibition: A Cell Assay to Measure Neuroprotection
CNS & Neurological Disorders - Drug Targets Nano Cocrystals: Crystal Engineering from a Nanotechnological Perspective
Current Pharmaceutical Design Recent Advances in Transition Metal-Catalyzed Reactions of Oxabenzonorbornadiene
Current Organic Synthesis Development of Recent Total Syntheses Based on the Heck Reaction
Current Organic Chemistry Neurocognitive Correlates in Driving Under the Influence of <I>Cannabis</i>
CNS & Neurological Disorders - Drug Targets Pathogenesis of Abeta Oligomers in Synaptic Failure
Current Alzheimer Research Editorial (Hot Topic: Computer-Aided Drug Design, Synthesis and Evaluation of New Anti-Cancer Drugs)
Current Topics in Medicinal Chemistry Cell and Gene Therapies for Refractory Epilepsy
Current Neuropharmacology Commentary: Multifactoriality of Amytrophic Lateral Sclerosis: Linking Unfolded Proteins to Oxidative Stress in Microglia
CNS & Neurological Disorders - Drug Targets Machine Learning and Perturbation Theory Machine Learning (PTML) in Medicinal Chemistry, Biotechnology, and Nanotechnology
Current Topics in Medicinal Chemistry Effects of an Outpatient Service Rehabilitation Programme in Patients Affected by Pulmonary Arterial Hypertension: An Observational Study
Cardiovascular & Hematological Disorders-Drug Targets