Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders

Title:Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders

Volume: 19 Issue: 6

Author(s): Paolo Boldrini*, Antonella Fusco, Ferdinando Nicoletti, Aldo Badiani and Luciano Saso

Affiliation:

• Department of Physiology and Pharmacology ,Italy

Keywords: Oxidative stress modulators, anxiety disorders, anxiety models, reactive oxygen species, reactive nitrogen species, lipid peroxidation.

Abstract: Background: It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders.

Objective: In this review, we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use.

Discussion and Conclusion: While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as an adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.

Cite this article as:

Boldrini Paolo *, Fusco Antonella , Nicoletti Ferdinando , Badiani Aldo and Saso Luciano, Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders, Current Drug Targets 2018; 19 (6) . https://dx.doi.org/10.2174/1389450118666170425153356