Microwave-assisted Olefin Metathesis as Pivotal Step in the Synthesis of Bioactive Compounds

Title:Microwave-assisted Olefin Metathesis as Pivotal Step in the Synthesis of Bioactive Compounds

Volume: 24 Issue: 41

Author(s): Koffi Senam Etse, Alice Ngendera, Nelly Tshibalonza Ntumba, Albert Demonceau*, Lionel Delaude, Ileana Dragutan and Valerian Dragutan

Affiliation:

• Laboratory of Macromolecular Chemistry and Organic Catalysis, Department of Chemistry, University of Liège, Sart-Tilman (B.6a), B-4000 Liege,Belgium

Keywords: Cross-metathesis, microwaves, natural products, olefin metathesis, ring-closing metathesis, ruthenium catalysts.

Abstract: Over the last two decades, olefin metathesis has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients. In many cases, syntheses based on olefin metathesis strategies provide significant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. On the other hand, over the last decade, microwave-assisted chemistry has experienced an incredible development, which rapidly opened new areas in organic synthesis and in homogeneous catalysis. In this review article, we highlight applications of microwaveheated olefin metathesis reactions as pivotal steps in the total synthesis of biologically active compounds. By drawing selected examples from the recent literature, we aim to illustrate the great synthetic power and variety of metathesis reactions, as well as the beneficial effects of microwave irradiation over conventional heating sources. The majority of the selected applications of microwave-assisted olefin metathesis cover the synthesis of medium-ring cycles, macrocycles, and peptidomimetics by means of ring-closing metathesis (RCM) and crossmetathesis (CM) routes.

Cite this article as:

Etse Senam Koffi , Ngendera Alice , Ntumba Tshibalonza Nelly , Demonceau Albert *, Delaude Lionel , Dragutan Ileana and Dragutan Valerian, Microwave-assisted Olefin Metathesis as Pivotal Step in the Synthesis of Bioactive Compounds, Current Medicinal Chemistry 2017; 24 (41) . https://dx.doi.org/10.2174/0929867324666170314122820