摘要
p75神经营养因子受体(p75NTR)是肿瘤坏死因子(TNF)死亡域含受体家族中的单一跨膜受体。 p75NTR通过与三种主要的神经营养因子受体(包括原肌球蛋白受体激酶(Trk),分拣蛋白和Nogo受体)配合,具有生物或致病功能的多个面。 通过与不同的共同受体配合,p75NTR调节成熟或促神经营养因子的结合和不同信号通路的激活,导致从生长和存活到细胞死亡或凋亡的结果。 在这篇综述中,我们总结了p75NTR在维持大脑止血中的作用,并简要介绍了其参与几种神经变性疾病的发病机制。 p75NTR的复杂性使其能够通过调节受体的功能成为许多疾病的有效治疗靶点。
关键词: p75神经营养因子受体,分拣蛋白,凋亡,神经发生,脑。
Current Alzheimer Research
Title:Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies
Volume: 14 Issue: 5
关键词: p75神经营养因子受体,分拣蛋白,凋亡,神经发生,脑。
摘要: The p75 neurotrophin receptor (p75NTR) is a single membrane-spanning receptor in the tumor necrosis factor (TNF) death domain containing receptor family. p75NTR has multiple faces of biological or pathogenic functions by partnering with the three major neurotrophin receptors, including tropomyosin receptor kinase (Trk), sortilin and Nogo receptors. By partnering with different co-receptors, p75NTR regulates the binding of mature or pro-neurotrophins and activation of different signaling pathways, resulting in outcomes ranging from growth and survival to cell death or apoptosis. In this review, we summarized the role of p75NTR in maintaining the hemostasis of the brain, and briefly introduced its participation in the pathogenesis of several neurodegenerative diseases. The complexity of p75NTR enables it to be a potent therapeutic target of many diseases by modulating functions of the receptor.
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Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies, Current Alzheimer Research 2017; 14 (5) . https://dx.doi.org/10.2174/1567205014666170110142415
DOI https://dx.doi.org/10.2174/1567205014666170110142415 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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