摘要
背景：细菌对常用抗菌药物的耐药性越来越大，迫使人们寻求替代或支持治疗感染的方法。靶向毒力因子就是其中之一。方法.细菌基因蛋白的强烈参与毒力和在许多情况下，缺乏对性功能鉴定病原菌。htras法下应力保护细胞成功的条件以及他们直接参与的主机的入侵。后者的功能主要是由最近发现的胞外部分HtrA玩。本文旨在对电动汽车进行综述。htras评价作为治疗目标，包括设计化学抑制剂和疫苗。 方法：我们对同行科学文献的书目数据库进行了彻底的研究。 结果：共纳入一百六十四篇论文。首先，我们简要地总结了关键的结构和功能已知HtrA proteins在外HtrA分数特别关注性能。然后我们提供的努力和进步目标病原菌htras作为保证的概述抗菌治疗。在某些情况下，取得了令人鼓舞的结果，htraspecific抑制剂保护组织免受破坏和杀死细菌的应用。也有令人鼓舞的报告关注荷兰HtrA使用在一些疾病模型的一种保护性抗原最近发表。 结论：本文的研究结果表明，出口HtrA蛋白由于其可达性很有前景的治疗靶点，在毒力和免疫原性的意义。然而此外，还需要进行广泛的研究，以开发安全的抗菌治疗。
关键词: Serine protease，变构酶，细菌感染，毒力因子，疫苗研制，选择性抑制，治疗性化合物的设计。
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