Abstract
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.
Keywords: Convection enhanced delivery, drug delivery system, glioblastoma, surrogate markers, tracers, blood brain barrier (BBB), Brain Tumors, macromolecules, surgical resection, radiation therapy
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