The Application of X-ray, NMR, and Molecular Modeling in the Design of MMP Inhibitors

Title: The Application of X-ray, NMR, and Molecular Modeling in the Design of MMP Inhibitors

Volume: 4 Issue: 12

Author(s): Thomas S. Rush III and Robert Powers

Affiliation:

Keywords: structure-based drug design, matrix metalloproteinase, matrix metalloprotease, x-ray, nmr, molecular modeling, inhibitor, mmp

Abstract: The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFα-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.

Cite this article as:

Rush III S. Thomas and Powers Robert, The Application of X-ray, NMR, and Molecular Modeling in the Design of MMP Inhibitors, Current Topics in Medicinal Chemistry 2004; 4 (12) . https://dx.doi.org/10.2174/1568026043387999