摘要
维生素D通过其受体,维生素D受体的作用在调节炎症、免疫应答和癌抑制中是一种重要的因素。近期的研究阐述了维生素D/维生素D受体在调节宿主-细菌相互作用的作用。益生菌是对宿主有益的细菌。本文我们介绍了近期维生素D/维生素D受体在肠道微生物和炎症中作用的研究进展。我们也对益生菌在调节维生素D及其受体和使健康与胃肠道疾病中肠道微生物达到平衡进行了综述。此外,我们将回顾益生菌在预防与治疗IBD或者结肠癌的临床应用。尽管有这些进展,但为了使益生菌在临床上得到更广泛的应用仍存在一些障碍。我们也几个科学地理解益生菌、维生素D及其受体和宿主应答方面的局限性和未来发展方向。
关键词: 自噬,细菌,结肠癌,结肠炎,乳酸杆菌,炎症肠道疾病,发炎,益生菌,NF-kB, 维生素D,维生素D受体
Current Medicinal Chemistry
Title:Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases
Volume: 24 Issue: 9
关键词: 自噬,细菌,结肠癌,结肠炎,乳酸杆菌,炎症肠道疾病,发炎,益生菌,NF-kB, 维生素D,维生素D受体
摘要: Vitamin D is an important factor in regulating inflammation, immune responses, and carcinoma inhibition via action of its receptor, vitamin D receptor (VDR). Recent studies have demonstrated the role of vitamin D/VDR in regulating host-bacterial interactions. Probiotics are beneficial bacteria with the power of supporting or favoring life on the host. In the current review, we will discuss the recent progress on the roles of vitamin D/VDR in gut microbiome and inflammation. We will summarize evidence of probiotics in modulating vitamin D/VDR and balancing gut microbiota in health and gastrointestinal diseases. Moreover, we will review the clinical application of probiotics in prevention and therapy of IBD or colon cancer. Despite of the gains, there remain several barriers to advocate broad use of probiotics in clinical therapy. We will also discuss the limits and future direction in scientific understanding of probiotics, vitamin D/VDR, and host responses.
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Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases, Current Medicinal Chemistry 2017; 24 (9) . https://dx.doi.org/10.2174/0929867323666161202150008
DOI https://dx.doi.org/10.2174/0929867323666161202150008 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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