摘要
维生素D通过其受体,维生素D受体的作用在调节炎症、免疫应答和癌抑制中是一种重要的因素。近期的研究阐述了维生素D/维生素D受体在调节宿主-细菌相互作用的作用。益生菌是对宿主有益的细菌。本文我们介绍了近期维生素D/维生素D受体在肠道微生物和炎症中作用的研究进展。我们也对益生菌在调节维生素D及其受体和使健康与胃肠道疾病中肠道微生物达到平衡进行了综述。此外,我们将回顾益生菌在预防与治疗IBD或者结肠癌的临床应用。尽管有这些进展,但为了使益生菌在临床上得到更广泛的应用仍存在一些障碍。我们也几个科学地理解益生菌、维生素D及其受体和宿主应答方面的局限性和未来发展方向。
关键词: 自噬,细菌,结肠癌,结肠炎,乳酸杆菌,炎症肠道疾病,发炎,益生菌,NF-kB, 维生素D,维生素D受体
Current Medicinal Chemistry
Title:Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases
Volume: 24 Issue: 9
关键词: 自噬,细菌,结肠癌,结肠炎,乳酸杆菌,炎症肠道疾病,发炎,益生菌,NF-kB, 维生素D,维生素D受体
摘要: Vitamin D is an important factor in regulating inflammation, immune responses, and carcinoma inhibition via action of its receptor, vitamin D receptor (VDR). Recent studies have demonstrated the role of vitamin D/VDR in regulating host-bacterial interactions. Probiotics are beneficial bacteria with the power of supporting or favoring life on the host. In the current review, we will discuss the recent progress on the roles of vitamin D/VDR in gut microbiome and inflammation. We will summarize evidence of probiotics in modulating vitamin D/VDR and balancing gut microbiota in health and gastrointestinal diseases. Moreover, we will review the clinical application of probiotics in prevention and therapy of IBD or colon cancer. Despite of the gains, there remain several barriers to advocate broad use of probiotics in clinical therapy. We will also discuss the limits and future direction in scientific understanding of probiotics, vitamin D/VDR, and host responses.
Export Options
About this article
Cite this article as:
Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases, Current Medicinal Chemistry 2017; 24 (9) . https://dx.doi.org/10.2174/0929867323666161202150008
DOI https://dx.doi.org/10.2174/0929867323666161202150008 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nanomedicine: Addressing Cardiovascular Disease and Cardiovascular Tissue Regeneration
Current Bioactive Compounds Preface [Hot Topic: Oxidative Balance: From Chemistry to Clinical Medicine (Executive Editor: Fortunato Vesce)]
Current Pharmaceutical Design Mesenchymal Stem Cells as Mediators of Neural Differentiation
Current Stem Cell Research & Therapy NAD+ Metabolism and NAD+-Dependent Enzymes: Promising Therapeutic Targets for Neurological Diseases
Current Drug Targets Exercise Induced Cardioprotection: An Overview of a Unique Form of Preconditioning
Current Cardiology Reviews Protective Effect of Natural Antioxidants on Heart Against Ischemia-Reperfusion Damage
Current Pharmaceutical Biotechnology The Chemical Biology of Immunophilin Ligands
Current Medicinal Chemistry Reversal of Cardiac Iron Loading and Dysfunction in Thalassemic Mice by Curcuminoids
Medicinal Chemistry Dexmedetomidine: A Review of its Use for the Management of Pain, Agitation, and Delirium in the Intensive Care Unit
Current Pharmaceutical Design HSP27: Mechanisms of Cellular Protection Against Neuronal Injury
Current Molecular Medicine The Possible Involvement of HLA Class III Haplotype (RAGE, HSP70 and TNF Genes) in Alzheimer's Disease
Current Alzheimer Research Cardiolipin Metabolism and the Role it Plays in Heart Failure and Mitochondrial Supercomplex Formation
Cardiovascular & Hematological Disorders-Drug Targets Protein Phosphatase Inhibition: Structure Based Design. Towards New Therapeutic Agents
Current Pharmaceutical Design Applied Pathology for Interventions of Coronary Chronic Total Occlusion
Current Cardiology Reviews Modulation of Staurosporine-Activated Volume-Sensitive Outwardly Rectifying Cl- Channel by PI3K/Akt in Cardiomyocytes
Current Pharmaceutical Design The Impact of Small Heat Shock Proteins (HspBs) in Alzheimer’s and Other Neurological Diseases
Current Pharmaceutical Design Curcumin Reverts the Protein Differential Expression in the Liver of the Diabetic Obese db/db Mice
Current Proteomics Non-Analgesic Effects of Opioids: Neuroprotection in the Retina
Current Pharmaceutical Design The Role of Apelins in the Physiology of the Heart
Protein & Peptide Letters Adenosine in the Inflamed Gut: A Janus Faced Compound
Current Medicinal Chemistry