Abstract
Background: Diabetes mellitus, a condition of multifactorial origin, is related to the intestinal microbiota by numerous molecular mechanisms. Controlling the vast increase in the prevalence of diabetes needs a natural and safe solution. Probiotics, known as live microorganisms that exert health benefits to the host, have anti-diabetic property.
Objective: This review will highlight the current evidences in probiotic effectiveness and future prospects for exploring probiotic therapy in the prevention and control of diabetes.
Methods: We searched Pub Med and Science Direct by using “Probiotics” and “Diabetes” for searching the studies aiming the application of probiotics and the beneficial effects of probiotics in diabetes prevention and control.
Results: It has been shown that probiotics can increase insulin sensitivity and reduce autoimmune responses by modulating intestinal microbiota and decreasing the inflammatory reactions and oxidative stress. Recent evidences show that probiotics influences the host through modulating intestinal permeability and mucosal immune response, manipulating eating behaviors by appetite-regulating hormones and controlling gut endocannabinoid (eCB) system that is believed to be associated with inflammation and diabetes. Moreover, modulating the intestinal microbiota by probiotics controls host metabolism by affecting energy extraction from food and by biochemically converting molecules derived from the host or from gut microbes themselves.
Conclusion: Experimental and clinical evidences support the hypothesis that the modulation of the gut microbiota by probiotics could be effective in prevention and management of diabetes.
Keywords: Diabetes, gut microbes, intestinal microbiota, probiotics, inflammatory, chronic diseases.
Current Diabetes Reviews
Title:The Future of Diabetes Management by Healthy Probiotic Microorganisms
Volume: 13 Issue: 6
Author(s): Aziz H. Rad, Shamsi Abbasalizadeh, Shabnam Vazifekhah, Fatemeh Abbasalizadeh, Tohid Hassanalilou, Parvin Bastani, Hanieh-Sadat Ejtahed, Ahmad-Reza Soroush, Mina Javadi, Amir M. Mortazavian and Leila Khalili*
Affiliation:
- Student of Nutrition, Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords: Diabetes, gut microbes, intestinal microbiota, probiotics, inflammatory, chronic diseases.
Abstract: Background: Diabetes mellitus, a condition of multifactorial origin, is related to the intestinal microbiota by numerous molecular mechanisms. Controlling the vast increase in the prevalence of diabetes needs a natural and safe solution. Probiotics, known as live microorganisms that exert health benefits to the host, have anti-diabetic property.
Objective: This review will highlight the current evidences in probiotic effectiveness and future prospects for exploring probiotic therapy in the prevention and control of diabetes.
Methods: We searched Pub Med and Science Direct by using “Probiotics” and “Diabetes” for searching the studies aiming the application of probiotics and the beneficial effects of probiotics in diabetes prevention and control.
Results: It has been shown that probiotics can increase insulin sensitivity and reduce autoimmune responses by modulating intestinal microbiota and decreasing the inflammatory reactions and oxidative stress. Recent evidences show that probiotics influences the host through modulating intestinal permeability and mucosal immune response, manipulating eating behaviors by appetite-regulating hormones and controlling gut endocannabinoid (eCB) system that is believed to be associated with inflammation and diabetes. Moreover, modulating the intestinal microbiota by probiotics controls host metabolism by affecting energy extraction from food and by biochemically converting molecules derived from the host or from gut microbes themselves.
Conclusion: Experimental and clinical evidences support the hypothesis that the modulation of the gut microbiota by probiotics could be effective in prevention and management of diabetes.
Export Options
About this article
Cite this article as:
Rad H. Aziz , Abbasalizadeh Shamsi , Vazifekhah Shabnam , Abbasalizadeh Fatemeh , Hassanalilou Tohid , Bastani Parvin , Ejtahed Hanieh-Sadat , Soroush Ahmad-Reza , Javadi Mina , Mortazavian M. Amir and Khalili Leila *, The Future of Diabetes Management by Healthy Probiotic Microorganisms, Current Diabetes Reviews 2017; 13 (6) . https://dx.doi.org/10.2174/1573399812666161014112515
DOI https://dx.doi.org/10.2174/1573399812666161014112515 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Influence of Lifestyle Measures on Hypertriglyceridaemia
Current Drug Targets Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade
Letters in Drug Design & Discovery microRNAs: Promising Biomarkers and Therapeutic Targets of Acute Myocardial Ischemia
Current Vascular Pharmacology Statin Therapy for Native and Peri-Interventional Coronary Heart Disease
Current Molecular Medicine Human Recombinant Leptin Administration as a Potential Obesity Therapy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Military Risk Factors for Cognitive Decline, Dementia and Alzheimer’s Disease
Current Alzheimer Research Patent Selections
Recent Patents on Anti-Infective Drug Discovery Editorial [ Reducing Cardiovascular Risk: Is Low-Density Lipoprotein-Cholesterol (LDL-C) Lowering Enough? ]
Current Vascular Pharmacology Jak2 and Reactive Oxygen Species: A Complex Relationship
Current Chemical Biology Goat Milk Frozen Yogurt Caja (Spondias mombin L.) Flavor: Development and Sensory Acceptance of an Exotic Food
Current Nutrition & Food Science Role of Matrix Metalloproteinases in Animal Models of Ischemic Stroke
Current Vascular Pharmacology The Bioenergetics of Isolated Mitochondria from Different Animal Models for Diabetes
Current Diabetes Reviews Macronutrient Specific Postprandial Oxidative Stress: Relevance to the Development of Insulin Resistance
Current Diabetes Reviews Thyroid Hormones and Cardiovascular System: From Bench to Bedside
Current Drug Therapy The Potential Use of Hormone-Based Therapeutics for the Treatment of Alzheimers Disease
Current Alzheimer Research Chemotherapy and Cardiotoxicity in Hematologic Malignancies
Current Cancer Drug Targets Chemistry and Pharmacology of Bioactive Molecule -Coenzyme Q10: A Brief Note
Current Bioactive Compounds Are Retinoids a Promise for Alzheimer’s Disease Management?
Current Medicinal Chemistry Antidiabetic Oils
Current Diabetes Reviews Long-Chain Omega-3 Fatty Acid Deficiency in Mood Disorders: Rationale for Treatment and Prevention
Current Drug Discovery Technologies