MDM2通过诱导EMT独立于p53增加肿瘤细胞的耐药性

Title:MDM2 Increases Drug Resistance in Cancer Cells by Inducing EMT Independent of p53

Volume: 23 Issue: 40

Author(s): Weichao Sun, Liling Tang

Affiliation:

关键词: Mdm2，Akt磷酸化，p53，耐药性，上皮间质转化。

摘要: Mdm2 is a well studied oncogene and has been reported to be closely related to chemoresistance in different manners. In this article, we discuss the current knowledge of mdm2’s function in drug resistance, the novel relationship between MDM2 and Akt phosphorylation, the role of Akt signaling pathway in epithelial-mesenchymal transition, and the positive correlation among MDM2, epithelial-mesenchymal transition and drug resistance. We propose a possible pathway by which MDM2 increases drug resistance through inducing epithelial-mesenchymal transition independent of p53. This pathway may play a significant role in the tumorigenesis and chemoresistance. By targeting MDM2, we can re-activate the function of p53, inhibit the epithelial-mesenchymal transition process and thus increase cancer cells sensitivity to chemotherapy. Thus, from p53-dependent and p53-independent aspects, it may present a better strategy for cancer treatment than targeting other genes.

Cite this article as:

Weichao Sun, Liling Tang , MDM2 Increases Drug Resistance in Cancer Cells by Inducing EMT Independent of p53, Current Medicinal Chemistry 2016; 23 (40) . https://dx.doi.org/10.2174/0929867323666160926150820