摘要
现代与生活习惯相关的疾病像癌症、心血管疾病和糖尿病的发病率在急剧上升,唤起研究者在探索自然资源作为新的治疗机制的兴趣。黄酮占广泛存在在人类饮食中的多酚中的大部分。它在对抗多种慢性疾病中表现出治疗前景。黄酮槲皮素是最广泛分布和研究最多的黄酮之一。它强大的抗氧化和抗炎活性被很好地证明并且被看做在治疗和对抗包括糖尿病、癌症、神经退行性疾病和心血管疾病中扮演了很重要的角色。本综述的目的是为证明槲皮素作为一种抗糖尿病药提供线索。槲皮素被报道与许多分子靶点在小肠、胰腺、骨骼肌、脂肪组织和肝脏控制整个机体葡萄糖平衡有相互作用。槲皮素的作用机制是多效性的,同时涉及肠道吸收、胰岛素分泌和胰岛素增敏剂的抑制和葡萄糖在外周组织中的利用。最初的研究显示槲皮素有较弱的利用度。然而,最近的报道显示槲皮素在血浆检测到的食物和补充剂消耗后,在体内有一个长的半衰期。尽管在体外体内的结果表明槲皮素有抗糖尿病的潜力,但它在治疗糖尿病人疗效方面还有待探讨。
关键词: 黄酮,胰岛素耐受性,葡萄糖的摄入,糖质新生,葡萄糖吸收,胰岛素分泌,AKPK,糖脂毒性。
Current Medicinal Chemistry
Title:The Antidiabetic Potential of Quercetin: Underlying Mechanisms
Volume: 24 Issue: 4
关键词: 黄酮,胰岛素耐受性,葡萄糖的摄入,糖质新生,葡萄糖吸收,胰岛素分泌,AKPK,糖脂毒性。
摘要: The dramatic increase in modern lifestyle diseases such as cancer, cardiovascular diseases and diabetes has renewed researchers’ interest to explore nature as a source of novel therapeutic agents. Flavonoids are a large group of polyphenols that are widely present in the human diet. They have shown promising therapeutic activities against a wide variety of ailments. One of the most widely distributed and most extensively studied flavonoid is the flavonol quercetin. Its powerful antioxidant and anti-inflammatory activities are well documented and are thought to play a role in treating and protecting against diseases including diabetes, cancer, neurodegenerative and cardiovascular diseases. The purpose of this review is to shed light on quercetin therapeutic potential as an antidiabetic agent. Quercetin was reported to interact with many molecular targets in small intestine, pancreas, skeletal muscle, adipose tissue and liver to control whole-body glucose homeostasis. Mechanisms of action of quercetin are pleiotropic and involve the inhibition of intestinal glucose absorption, insulin secretory and insulin-sensitizing activities as well as improved glucose utilization in peripheral tissues. Initial studies suggested poor bioavailability of quercetin. However, recent reports have shown that quercetin was detected in the plasma after food or supplements consumption and has a long half-life in human body. Despite the wealth of in vitro and in vivo results supporting the antidiabetic potential of quercetin, its efficacy in diabetic human subjects is yet to be explored.
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The Antidiabetic Potential of Quercetin: Underlying Mechanisms, Current Medicinal Chemistry 2017; 24 (4) . https://dx.doi.org/10.2174/0929867323666160909153707
DOI https://dx.doi.org/10.2174/0929867323666160909153707 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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