Advances in the Physiology of GPR55 in the Central Nervous System

Title:Advances in the Physiology of GPR55 in the Central Nervous System

Volume: 15 Issue: 5

Author(s): Bruno A. Marichal-Cancino*, Alfonso Fajardo-Valdez, Alejandra E. Ruiz-Contreras, Monica Mendez-Díaz and Oscar Prospero-García*

Affiliation:

• Department of Physiology, Faculty of Medicine, UNAM, P.O. Box: 70-250, Mexico City,Mexico

• Department of Physiology, Faculty of Medicine, UNAM, P.O. Box: 70-250, Mexico City,Mexico

Keywords: GPR55, endocannabinoid system, central nervous system, lysophosphatidylinositol, procedural memory.

Abstract: Background: The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucidated.

Methods: A bibliographic search in PubMed database about GPR55 actions in the CNS was made. The information was grouped for brain structures to facilitate the interpretation. Finally, we constructed a schematic representation of the current knowledge about the potential participation of GPR55 in some physiological and pathophysiological events.

Results: Seventy nine papers were included in the review. Only few of them showed data about GPR55 (mRNA/protein) expression in multiple brain areas. The rest showed findings in different preparations both in vitro and in vivo conditions that allowed us to speculate a potential activity of GPR55 in the different brain areas.

Conclusion: GPR55 mRNA is expressed in several brain areas as the hippocampus, hypothalamus, frontal cortex and cerebellum; but due to the lack of information, only some speculative information about its function in these regions has been suggested. Therefore, this review provide relevant information to motivate further research about GPR55 physiology/pathophysiology in the CNS.

Cite this article as:

A. Marichal-Cancino Bruno*, Fajardo-Valdez Alfonso, E. Ruiz-Contreras Alejandra, Mendez-Díaz Monica and Prospero-García Oscar*, Advances in the Physiology of GPR55 in the Central Nervous System, Current Neuropharmacology 2017; 15 (5) . https://dx.doi.org/10.2174/1570159X14666160729155441

DOI https://dx.doi.org/10.2174/1570159X14666160729155441	Print ISSN 1570-159X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6190