Promising Potential of Dietary (Poly)Phenolic Compounds in the Prevention and Treatment of Diabetes Mellitus

Title:Promising Potential of Dietary (Poly)Phenolic Compounds in the Prevention and Treatment of Diabetes Mellitus

Volume: 24 Issue: 4

Author(s): Tania R. Dias, Marco G. Alves, Susana Casal, Pedro F. Oliveira and Branca M. Silva*

Affiliation:

• Centro de Investigacao, em Ciencias da Saude (CICS-UBI), Universidade da Beira Interior, Rua Marques d'Avila e Bolama, 6201-001, Covilha,Portugal

Keywords: Human health, prediabetes, diabetes mellitus, phytochemicals, diet, (Poly)phenols, antioxidants.

Abstract: Background: The incidence of diabetes mellitus (DM) is reaching alarming proportions worldwide, particularly because it is increasingly affecting younger people. This reflects the sedentary lifestyle and inappropriate dietary habits, especially due to the advent of processed foods in modern societies. Thus, unsurprisingly, the first medical recommendation to patients with clinically evident DM is the alteration in their eating behaviour, particularly regarding carbohydrates and total energy intake. Despite individual and cultural preferences, human diet makes available a large amount of phytochemicals with therapeutic potential. Phenolic compounds are the most abundant class of phytochemicals in edible plants, fruits and beverages. These compounds have strong antioxidant and anti-inflammatory activities that have been associated with specific features of their chemical structure. Among others, such properties make them promising antidiabetic agents and several mechanisms of action have already been proposed.

Objective: Herein, we discuss the recent findings on the potential of dietary phenolic compounds for the prevention and/or treatment of (pre)diabetes, and associated complications.

Conclusion: A broad range of studies supports the innate potential of phenolic compounds to protect against DM-associated deleterious effects. Their antidiabetic activity has been demonstrated by: i) regulation of carbohydrate metabolism; ii) improvement of glucose uptake; iii) protection of pancreatic β-cells; iv) enhancement of insulin action and v) regulation of crucial signalling pathways to cell homeostasis. Dietary phenolic compounds constitute an easy, safe and cost-effective way to combat the worrying scenario of DM. The interesting particularities of phenolic compounds reinforce the implementation of a (poly)phenolic-rich nutritional regime, not only for (pre)diabetic patients, but also for non-diabetic people.

Cite this article as:

Dias R. Tania, Alves G. Marco, Casal Susana , Oliveira F. Pedro and Silva M. Branca *, Promising Potential of Dietary (Poly)Phenolic Compounds in the Prevention and Treatment of Diabetes Mellitus, Current Medicinal Chemistry 2017; 24 (4) . https://dx.doi.org/10.2174/0929867323666160905150419

DOI https://dx.doi.org/10.2174/0929867323666160905150419	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X