摘要
背景:糖尿病(DM)在全世界的发生率已经接近惊人的数据,特别是因为它越来越多影响了年轻人。这反映了久坐的生活习惯和不适当的饮食习惯,尤其是现代社会中加工食品的出现。因此,毫不惊奇的,第一医疗建议那些有着明显的临床糖尿病的病人改变他们的饮食行为,特别是碳水化合物和总能量的摄入。尽管个体和文化的偏好,人类饮食提供了大量具有治疗潜力的植物化学物质。在可食用的植物、水果和饮料中,酚类化合物是种类最多的植物化学物质。这些化合物有着很强的抗氧化和抗炎症活性,这些性质与他们特殊的结构特征相关。其中,这些特性使他们有前景的抗糖尿病和集中活性机制被很早的提出。 目的:于此,我们讨论目前在潜在膳食酚类化合物在预防和治疗(前期)糖尿病及相关并发症方面的研究。 结论:一系列广泛的研究支持。他们抗糖尿病的活性通过以下几点已经被证明:1、碳水化合物代谢的调控。2、葡萄糖摄入的改善。3、胰腺b细胞的保护。4、胰岛素活性的增强。5、关键信号通路对细胞动态平衡的调节。膳食酚类化合物由一个简单、安全又合算的方式对抗糖尿病令人担忧的情况。酚类化合物有趣的增强实现(多元)酚类富营养的体制,不仅应用于(前期)糖尿病人群,而且适用于非糖尿病人群。
关键词: 人类健康,糖尿病前期,糖尿病,植物化学,饮食,(多元)酚类,抗氧化剂
Current Medicinal Chemistry
Title:Promising Potential of Dietary (Poly)Phenolic Compounds in the Prevention and Treatment of Diabetes Mellitus
Volume: 24 Issue: 4
关键词: 人类健康,糖尿病前期,糖尿病,植物化学,饮食,(多元)酚类,抗氧化剂
摘要: Background: The incidence of diabetes mellitus (DM) is reaching alarming proportions worldwide, particularly because it is increasingly affecting younger people. This reflects the sedentary lifestyle and inappropriate dietary habits, especially due to the advent of processed foods in modern societies. Thus, unsurprisingly, the first medical recommendation to patients with clinically evident DM is the alteration in their eating behaviour, particularly regarding carbohydrates and total energy intake. Despite individual and cultural preferences, human diet makes available a large amount of phytochemicals with therapeutic potential. Phenolic compounds are the most abundant class of phytochemicals in edible plants, fruits and beverages. These compounds have strong antioxidant and anti-inflammatory activities that have been associated with specific features of their chemical structure. Among others, such properties make them promising antidiabetic agents and several mechanisms of action have already been proposed.
Objective: Herein, we discuss the recent findings on the potential of dietary phenolic compounds for the prevention and/or treatment of (pre)diabetes, and associated complications. Conclusion: A broad range of studies supports the innate potential of phenolic compounds to protect against DM-associated deleterious effects. Their antidiabetic activity has been demonstrated by: i) regulation of carbohydrate metabolism; ii) improvement of glucose uptake; iii) protection of pancreatic β-cells; iv) enhancement of insulin action and v) regulation of crucial signalling pathways to cell homeostasis. Dietary phenolic compounds constitute an easy, safe and cost-effective way to combat the worrying scenario of DM. The interesting particularities of phenolic compounds reinforce the implementation of a (poly)phenolic-rich nutritional regime, not only for (pre)diabetic patients, but also for non-diabetic people.Export Options
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Cite this article as:
Promising Potential of Dietary (Poly)Phenolic Compounds in the Prevention and Treatment of Diabetes Mellitus, Current Medicinal Chemistry 2017; 24 (4) . https://dx.doi.org/10.2174/0929867323666160905150419
DOI https://dx.doi.org/10.2174/0929867323666160905150419 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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