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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Female Infertility and Cardiovascular Risk - A Hype or an Underestimated Reality?

Author(s): Julia K. Bosdou*, Panagiotis Anagnostis, George T. Lainas and Efstratios M. Kolibianakis

Volume 26, Issue 43, 2020

Page: [5551 - 5555] Pages: 5

DOI: 10.2174/1381612826666200821114552

Price: $65

Abstract

Infertility may be an early indicator of later-life health risk development, such as cardiovascular disease (CVD), the leading cause of death globally. Various infertility-associated factors such as female age, polycystic ovarian syndrome, endometriosis and metabolic syndrome are also risk factors for CVD. Whether there is a real association between female infertility and CVD, given that common pathways lead to both entities, or since both female infertility and CVD share a common basis, needs to be further investigated. If such an association is confirmed, infertile women might benefit from the initiation of preventive strategies aiming to control CVD risk factors. Thus, female infertility may represent an early indicator of future CVD and concomitantly a unique opportunity to identify women at increased risk for developing CVD. It is therefore imperative that large population- based studies are performed to elucidate this issue further and promote public awareness, if necessary.

Keywords: Female infertility, cardiovascular disease, arterial hypertension, diabetes mellitus, dyslipidemia, CVD.

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[1]
HRP annual report 2018. Geneva: World Health Organization 2019. Available at: https://www.who.int/reproductivehealth/publications/reports/hrp-annual-report-2018/en/
[2]
Zegers-Hochschild F, Adamson GD, de Mouzon J, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary on ART Terminology, 2009. Hum Reprod 2009; 24(11): 2683-7.
[http://dx.doi.org/10.1093/humrep/dep343] [PMID: 19801627]
[3]
Calhaz-Jorge C, de Geyter C, Kupka MS, et al. Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. Hum Reprod 2016; 31(8): 1638-52.
[http://dx.doi.org/10.1093/humrep/dew151] [PMID: 27496943]
[4]
Barbuscia A, Myrskylä M, Goisis A. The psychosocial health of children born after medically assisted reproduction: Evidence from the UK Millennium Cohort Study. SSM Popul Health 2019.7100355
[http://dx.doi.org/10.1016/j.ssmph.2019.100355] [PMID: 30723770]
[5]
Cedars MI, Taymans SE, DePaolo LV, et al. The sixth vital sign: what reproduction tells us about overall health. Proceedings from a NICHD/CDC workshop. Hum Reprod Open: 2017(2); hox008
[6]
Senapati S. Infertility: a marker of future health risk in women? Fertil Steril 2018; 110(5): 783-9.
[http://dx.doi.org/10.1016/j.fertnstert.2018.08.058] [PMID: 30316412]
[7]
Xu J, Murphy SL, Kochanek KD, Arias E. Mortality in the United States, 2015. NCHS Data Brief 2016; (267): 1-8.
[PMID: 27930283]
[8]
Dayan N, Filion KB, Okano M, et al. Cardiovascular Risk Following Fertility Therapy: Systematic Review and Meta-Analysis. J Am Coll Cardiol 2017; 70(10): 1203-13.
[http://dx.doi.org/10.1016/j.jacc.2017.07.753] [PMID: 28859782]
[9]
Bungum AB, Glazer CH, Arendt LH, et al. Risk of hospitalization for early onset of cardiovascular disease among infertile women: a register-based cohort study. Hum Reprod 2019; 34(11): 2274-81.
[http://dx.doi.org/10.1093/humrep/dez154] [PMID: 31665298]
[10]
Pepine CJ, Park K. Fertility Therapy and Long-Term Cardiovascular Risk: Raising More Questions Than Answers? J Am Coll Cardiol 2017; 70(10): 1214-5.
[http://dx.doi.org/10.1016/j.jacc.2017.07.731] [PMID: 28859783]
[11]
Udell JA, Lu H, Redelmeier DA. Long-term cardiovascular risk in women prescribed fertility therapy. J Am Coll Cardiol 2013; 62(18): 1704-12.
[http://dx.doi.org/10.1016/j.jacc.2013.05.085] [PMID: 23916924]
[12]
Gleason JL, Shenassa ED, Thoma ME. Self-reported infertility, metabolic dysfunction, and cardiovascular events: a cross-sectional analysis among U.S. women. Fertil Steril 2019; 111(1): 138-46.
[http://dx.doi.org/10.1016/j.fertnstert.2018.10.009] [PMID: 30458992]
[13]
Parikh NI, Cnattingius S, Mittleman MA, Ludvigsson JF, Ingelsson E. Subfertility and risk of later life maternal cardiovascular disease. Hum Reprod 2012; 27(2): 568-75.
[http://dx.doi.org/10.1093/humrep/der400] [PMID: 22131387]
[14]
Ge SQ, Tao X, Cai LS, Deng XY, Hwang MF, Wang CL. Associations of hormonal contraceptives and infertility medications on the risk of venous thromboembolism, ischemic stroke, and cardiovascular disease in women. J Investig Med 2019; 67(4): 729-35.
[http://dx.doi.org/10.1136/jim-2018-000750] [PMID: 30478156]
[15]
Udell JA, Lu H, Redelmeier DA. Failure of fertility therapy and subsequent adverse cardiovascular events. CMAJ 2017; 189(10): E391-7.
[http://dx.doi.org/10.1503/cmaj.160744] [PMID: 28385819]
[16]
Tobias DK, Gaskins AJ, Missmer SA, et al. History of infertility and risk of type 2 diabetes mellitus: a prospective cohort study. Diabetologia 2015; 58(4): 707-15.
[http://dx.doi.org/10.1007/s00125-015-3493-z] [PMID: 25596853]
[17]
Kurabayashi T, Mizunuma H, Kubota T, Hayashi K. Ovarian infertility is associated with cardiovascular disease risk factors in later life: A Japanese cross-sectional study. Maturitas 2016; 83: 33-9.
[http://dx.doi.org/10.1016/j.maturitas.2015.08.015] [PMID: 26417693]
[18]
Mahalingaiah S, Sun F, Cheng JJ, Chow ET, Lunetta KL, Murabito JM. Cardiovascular risk factors among women with self-reported infertility. Fertil Res Pract 2017; 3: 7.
[http://dx.doi.org/10.1186/s40738-017-0034-0] [PMID: 28620545]
[19]
Farland LV, Grodstein F, Srouji SS, et al. Infertility, fertility treatment, and risk of hypertension. Fertil Steril 2015; 104(2): 391-7.
[http://dx.doi.org/10.1016/j.fertnstert.2015.04.043] [PMID: 26049054]
[20]
Westerlund E, Brandt L, Hovatta O, Wallén H, Ekbom A, Henriksson P. Incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization: a population-based cohort study from Sweden. Fertil Steril 2014; 102(4): 1096-102.
[http://dx.doi.org/10.1016/j.fertnstert.2014.06.024] [PMID: 25064407]
[21]
Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 2010; 16(4): 347-63.
[http://dx.doi.org/10.1093/humupd/dmq001] [PMID: 20159883]
[22]
Anagnostis P, Tarlatzis BC, Kauffman RP. Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences. Metabolism 2018; 86: 33-43.
[http://dx.doi.org/10.1016/j.metabol.2017.09.016] [PMID: 29024702]
[23]
Cussons AJ, Stuckey BG, Watts GF. Cardiovascular disease in the polycystic ovary syndrome: new insights and perspectives. Atherosclerosis 2006; 185(2): 227-39.
[http://dx.doi.org/10.1016/j.atherosclerosis.2005.10.007] [PMID: 16313910]
[24]
Meyer C, McGrath BP, Cameron J, Kotsopoulos D, Teede HJ. Vascular dysfunction and metabolic parameters in polycystic ovary syndrome. J Clin Endocrinol Metab 2005; 90(8): 4630-5.
[http://dx.doi.org/10.1210/jc.2004-1487] [PMID: 15870132]
[25]
Teede HJ, Hutchison S, Zoungas S, Meyer C. Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS. Endocrine 2006; 30(1): 45-53.
[http://dx.doi.org/10.1385/ENDO:30:1:45] [PMID: 17185791]
[26]
de Groot PC, Dekkers OM, Romijn JA, Dieben SW, Helmerhorst FM. PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Hum Reprod Update 2011; 17(4): 495-500.
[http://dx.doi.org/10.1093/humupd/dmr001] [PMID: 21335359]
[27]
Zhao L, Zhu Z, Lou H, et al. Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis. Oncotarget 2016; 7(23): 33715-21.
[http://dx.doi.org/10.18632/oncotarget.9553] [PMID: 27220885]
[28]
Ramezani Tehrani F, Amiri M, Behboudi-Gandevani S, Bidhendi-Yarandi R, Carmina E. Cardiovascular events among reproductive and menopausal age women with polycystic ovary syndrome: a systematic review and meta-analysis. Gynecol Endocrinol 2020; 36(1): 12-23.
[http://dx.doi.org/10.1080/09513590.2019.1650337] [PMID: 31385729]
[29]
Bilal M, Haseeb A, Rehman A. Relationship of Polycystic Ovarian Syndrome with Cardiovascular Risk Factors. Diabetes Metab Syndr 2018; 12(3): 375-80.
[http://dx.doi.org/10.1016/j.dsx.2018.01.006] [PMID: 29396250]
[30]
Arumugam K, Majeed N. The polycystic ovarian syndrome and infertility: a metabolic disorder that needs early diagnosis and treatment. J Health Trans Med 2011; 14(1): 6-9.
[31]
Mu F, Rich-Edwards J, Rimm EB, Spiegelman D, Missmer SA. Endometriosis and Risk of Coronary Heart Disease. Circ Cardiovasc Qual Outcomes 2016; 9(3): 257-64.
[http://dx.doi.org/10.1161/CIRCOUTCOMES.115.002224] [PMID: 27025928]
[32]
Mu F, Rich-Edwards J, Rimm EB, Spiegelman D, Forman JP, Missmer SA. Association Between Endometriosis and Hypercholesterolemia or Hypertension. Hypertension 2017; 70(1): 59-65.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09056] [PMID: 28559401]
[33]
Kinugasa S, Shinohara K, Wakatsuki A. Increased asymmetric dimethylarginine and enhanced inflammation are associated with impaired vascular reactivity in women with endometriosis. Atherosclerosis 2011; 219(2): 784-8.
[http://dx.doi.org/10.1016/j.atherosclerosis.2011.08.005] [PMID: 21880316]
[34]
Santoro L, D’Onofrio F, Campo S, et al. Endothelial dysfunction but not increased carotid intima-media thickness in young European women with endometriosis. Hum Reprod 2012; 27(5): 1320-6.
[http://dx.doi.org/10.1093/humrep/des062] [PMID: 22416009]
[35]
Verit FF, Yildiz Zeyrek F, Zebitay AG, Akyol H. Cardiovascular risk may be increased in women with unexplained infertility. Clin Exp Reprod Med 2017; 44(1): 28-32.
[http://dx.doi.org/10.5653/cerm.2017.44.1.28] [PMID: 28428941]
[36]
Luke B, Brown MB. Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age. Hum Reprod 2007; 22(5): 1264-72.
[http://dx.doi.org/10.1093/humrep/del522] [PMID: 17289684]
[37]
Schmidt L, Sobotka T, Bentzen JG, Nyboe Andersen A. Demographic and medical consequences of the postponement of parenthood. Hum Reprod Update 2012; 18(1): 29-43.
[http://dx.doi.org/10.1093/humupd/dmr040] [PMID: 21989171]
[38]
Bosdou JK, Anagnostis P, Goulis DG, et al. Risk of gestational diabetes mellitus in women achieving singleton pregnancy spontaneously or after ART: a systematic review and meta-analysis. Hum Reprod Update 2020; 26(4): 514-44.
[http://dx.doi.org/10.1093/humupd/dmaa011] [PMID: 32441298]
[39]
Gui J, Ling Z, Hou X, Fan Y, Xie K, Shen R. In vitro fertilization is associated with the onset and progression of preeclampsia. Placenta 2020; 89: 50-7.
[http://dx.doi.org/10.1016/j.placenta.2019.09.011] [PMID: 31675490]
[40]
Roos-Hesselink JW, Johnson MR. Does fertility therapy hamper cardiovascular outcome? J Am Coll Cardiol 2013; 62(18): 1713-4.
[http://dx.doi.org/10.1016/j.jacc.2013.07.012] [PMID: 23916942]
[41]
Leon LJ, McCarthy FP, Direk K, et al. Preeclampsia and Cardiovascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records: A CALIBER Study. Circulation 2019; 140(13): 1050-60.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038080] [PMID: 31545680]
[42]
Legro RS. Polycystic ovary syndrome and cardiovascular disease: a premature association? Endocr Rev 2003; 24(3): 302-12.
[http://dx.doi.org/10.1210/er.2003-0004] [PMID: 12788801]
[43]
Muka T, Oliver-Williams C, Kunutsor S, et al. Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality: A Systematic Review and Meta-analysis. JAMA Cardiol 2016; 1(7): 767-76.
[http://dx.doi.org/10.1001/jamacardio.2016.2415] [PMID: 27627190]
[44]
Anagnostis P, Christou K, Artzouchaltzi AM, et al. Early menopause and premature ovarian insufficiency are associated with increased risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Endocrinol 2019; 180(1): 41-50.
[http://dx.doi.org/10.1530/EJE-18-0602] [PMID: 30400047]
[45]
Honigberg MC, Zekavat SM, Aragam K, et al. Association of premature natural ad surgical menopause with incident cardiovascular disease. JAMA 2019. In press
[46]
Anagnostis P, Theocharis P, Lallas K, et al. Early menopause is associated with increased risk of arterial hypertension: A systematic review and meta-analysis. Maturitas 2020; 135: 74-9.
[http://dx.doi.org/10.1016/j.maturitas.2020.03.006] [PMID: 32252968]
[47]
Zhu D, Chung HF, Dobson AJ, et al. Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: pooled analysis of individual data from 10 international studies. Hum Reprod 2020; 35(8): 1933-43.
[http://dx.doi.org/10.1093/humrep/deaa124] [PMID: 32563191]
[48]
Appt SE, Chen H, Clarkson TB, Kaplan JR. Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosis. Menopause 2012; 19(12): 1353-9.
[http://dx.doi.org/10.1097/gme.0b013e31825b4fe2] [PMID: 22929037]
[49]
de Kat AC, Verschuren WM, Eijkemans MJ, Broekmans FJ, van der Schouw YT. Anti-Müllerian Hormone Trajectories Are Associated With Cardiovascular Disease in Women: Results From the Doetinchem Cohort Study. Circulation 2017; 135(6): 556-65.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025968] [PMID: 28153992]
[50]
Andrews FM, Abbey A, Halman LJ. Stress from infertility, marriage factors, and subjective well-being of wives and husbands. J Health Soc Behav 1991; 32(3): 238-53.
[http://dx.doi.org/10.2307/2136806] [PMID: 1940208]
[51]
Steptoe A, Kivimäki M. Stress and cardiovascular disease. Nat Rev Cardiol 2012; 9(6): 360-70.
[http://dx.doi.org/10.1038/nrcardio.2012.45] [PMID: 22473079]
[52]
Reis JP, von Mühlen D, Michos ED, et al. Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis. Atherosclerosis 2009; 207(2): 585-90.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.05.030] [PMID: 19539290]
[53]
Anagnostis P, Athyros VG, Adamidou F, Florentin M, Karagiannis A. Vitamin D and cardiovascular disease: a novel agent for reducing cardiovascular risk? Curr Vasc Pharmacol 2010; 8(5): 720-30.
[http://dx.doi.org/10.2174/157016110792006978] [PMID: 20180765]
[54]
Bosdou JK, Konstantinidou E, Anagnostis P, Kolibianakis EM, Goulis DG, Vitamin D. Vitamin D and Obesity: Two Interacting Players in the Field of Infertility. Nutrients 2019; 11(7)E1455
[http://dx.doi.org/10.3390/nu11071455] [PMID: 31252555]
[55]
Anagnostis P, Karras S, Goulis DG. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013; 67(3): 225-35.
[http://dx.doi.org/10.1111/ijcp.12031] [PMID: 23294318]
[56]
Chu J, Gallos I, Tobias A, Tan B, Eapen A, Coomarasamy A. Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis. Hum Reprod 2018; 33(1): 65-80.
[http://dx.doi.org/10.1093/humrep/dex326] [PMID: 29149263]
[57]
Hassan E, Creatsas G, Mastorakos G, Michalas S. Clinical implications of the ovarian/endometrial renin-angiotensin-aldosterone system. Ann N Y Acad Sci 2000; 900: 107-18.
[http://dx.doi.org/10.1111/j.1749-6632.2000.tb06221.x] [PMID: 10818397]
[58]
Morris RS, Paulson RJ. Increased angiotensin-converting enzyme activity in a patient with severe ovarian hyperstimulation syndrome. Fertil Steril 1999; 71(3): 562-3.
[http://dx.doi.org/10.1016/S0015-0282(98)00471-3] [PMID: 10065799]
[59]
Magiakou MA, Mastorakos G, Webster E, Chrousos GP. The hypothalamic-pituitary-adrenal axis and the female reproductive system. Ann N Y Acad Sci 1997; 816: 42-56.
[http://dx.doi.org/10.1111/j.1749-6632.1997.tb52128.x] [PMID: 9238254]
[60]
Cameron A. The metabolic syndrome: validity and utility of clinical definitions for cardiovascular disease and diabetes risk prediction. Maturitas 2010; 65(2): 117-21.
[http://dx.doi.org/10.1016/j.maturitas.2009.11.026 ] [PMID: 20031349]

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