Abstract
A simple and efficient method has been developed for the synthesis of a new collection of isatin and 5-isatinylidenerhodanine derivatives carrying furan group, from N-(carboxymethyl)isatin through a multi-component reaction is explained. The reactive 1:1 intermediate formed from the reaction of isocyanides and dialkyl acetylenedicarboxylates was trapped at reflux temperature using N-(carboxymethyl)isatin derivatives to produce poly functionalized furan rings in good yields.
Keywords: 2, 5-diaminofurans, N-(carboxymethyl)isatin, isocynides, dialkyl acetylenedicarboxylates, rhodanine..
Graphical Abstract
Letters in Organic Chemistry
Title:Multicomponent Synthesis of Novel Class of Isatin and 5-isatinyli-denerhodanine Based Diaminofuran Derivatives
Volume: 13 Issue: 6
Author(s): Robabeh Baharfar and Somayeh Rassi
Affiliation:
Keywords: 2, 5-diaminofurans, N-(carboxymethyl)isatin, isocynides, dialkyl acetylenedicarboxylates, rhodanine..
Abstract: A simple and efficient method has been developed for the synthesis of a new collection of isatin and 5-isatinylidenerhodanine derivatives carrying furan group, from N-(carboxymethyl)isatin through a multi-component reaction is explained. The reactive 1:1 intermediate formed from the reaction of isocyanides and dialkyl acetylenedicarboxylates was trapped at reflux temperature using N-(carboxymethyl)isatin derivatives to produce poly functionalized furan rings in good yields.
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Cite this article as:
Baharfar Robabeh and Rassi Somayeh, Multicomponent Synthesis of Novel Class of Isatin and 5-isatinyli-denerhodanine Based Diaminofuran Derivatives, Letters in Organic Chemistry 2016; 13 (6) . https://dx.doi.org/10.2174/1570178613666160802145006
DOI https://dx.doi.org/10.2174/1570178613666160802145006 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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