摘要
背景和目标:胰岛素降解酶(IDE)导致 Aβ和胰岛素降解过程。我们旨在调查胰岛素降解酶在受其他因素的影响2型糖尿病轻度认知障碍患者中的作用。 方法:总共146名2型糖尿病患者,根据蒙特利尔认知评估(MoCA)评分分成两部分。考核人口特点,认知功能与血清水平胰岛素降解酶。 结果:有75例轻度认知障碍患者与71例非轻度认知障碍患者。相较于控制组(P<0.001),轻度认知障碍糖尿病患者有高水平血清胰岛素降解酶。在轻度认知障碍患者中,血清胰岛素降解酶水平与蒙特利尔认知评估评分正向相关(r = 0.839;P<0.001)。相关分析显示 胰岛素降解酶与MOCA评分正相关(r = 0.815;P<0.001),但与Trail Making Test-B (r = −0.413; p < 0.001))负相关,空腹血糖(R =−为0.372;P<0.001),糖基化修饰血红蛋白(R =−0.214;P=0.015),homeostasis模型评估所有主体中胰岛素抵抗(r = −0.560; p < 0.001和平均振幅(r = −0.551; p < 0.001)。Logistic回归分析表明,轻度认知障碍,胰岛素降解酶 (P = 0.010)是一个独立变量,在调整年龄,性别,职业,教育,和肝功能,肾功能,血脂水平之后。 结论:在本研究表明 轻度认知障碍患者2型糖尿病下降水平的血清胰岛素降解酶可能性很大。
关键词: 胰岛素抵抗稳态模型评估法,胰岛素降解酶,轻度认知功能障碍,平均血糖波动幅度,连线测试B,2型糖尿病
Current Alzheimer Research
Title:Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment
Volume: 13 Issue: 12
Author(s): Jie Sun, Wenqing Xia, Rongrong Cai, Pin Wang, Rong Huang, Haixia Sun, Sai Tian, Xue Dong, Shaohua Wang
Affiliation:
关键词: 胰岛素抵抗稳态模型评估法,胰岛素降解酶,轻度认知功能障碍,平均血糖波动幅度,连线测试B,2型糖尿病
摘要: Background and Aims: Insulin degrading enzyme (IDE) contributes to the degradation processes of insulin and Aβ. We aimed to investigate the role of IDE in type 2 diabetes patients with mild cognitive impairment (MCI).
Methods: A total of 146 individuals with type 2 diabetes were enrolled and divided into two groups according to the Montreal Cognitive Assessment (MoCA) score. Demographic characteristics, cognitive function and serum IDE level were examined.
Results: There were 75 patients with MCI and 71 patients without MCI. Diabetic patients with MCI had a higher serum level of IDE compared with the control group (p < 0.001). Among patients with MCI, serum IDE level was positively correlated with the MoCA score (r = 0.839; p < 0.001). Correlation analysis demonstrated that IDE was positively correlated with MoCA score (r = 0.815; p < 0.001) but negatively correlated with the Trail Making Test-B (r = −0.413; p < 0.001), fasting blood-glucose (r = −0.372; p < 0.001), glycosylated hemoglobin (r = −0.214; p = 0.015), homeostasis model of assessment for insulin resistance (r = −0.560; p < 0.001) and the mean amplitude of glycemic excursions (r = −0.551; p < 0.001) in all subjects. In logistic regression analysis for MCI, IDE (p = 0.010) was an independent variable, after adjusting for age, sex, education, liver function, kidney function, and lipid levels.
Conclusion: This study demonstrated a greater likelihood of MCI with decreasing serum IDE in patients with type 2 diabetes.
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Cite this article as:
Jie Sun, Wenqing Xia, Rongrong Cai, Pin Wang, Rong Huang, Haixia Sun, Sai Tian, Xue Dong, Shaohua Wang , Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment, Current Alzheimer Research 2016; 13 (12) . https://dx.doi.org/10.2174/1567205013666160615091043
DOI https://dx.doi.org/10.2174/1567205013666160615091043 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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