Abstract
The porphyrins and related tetrapyrrole systems are among the most widely studied of all macrocyclic compounds. In fact, in one capacity or another these versatile molecules have influenced nearly all disciplines in chemistry. In recent years, efforts are underway to develop tetrahydroporphyrin-based (bacteriochlorin) compounds with long wavelength absorption in the range of 700-800 nm as photosensitizers for photodynamic therapy (PDT). This review article summarizes the synthetic methodologies that have been developed for the preparation of a variety of bacteriochlorins, either from porphyrins or chlorin systems.
Keywords: bacteriochlorins photodynamictherapy (pdt), tetrapyrrole systems, photosensitizers
Current Organic Chemistry
Title: Synthesis of Bacteriochlorins and Their Potential Utility in Photodynamic Therapy (PDT)
Volume: 8 Issue: 12
Author(s): Yihui Chen, Guolin Li and Ravindra K. Pandey
Affiliation:
Keywords: bacteriochlorins photodynamictherapy (pdt), tetrapyrrole systems, photosensitizers
Abstract: The porphyrins and related tetrapyrrole systems are among the most widely studied of all macrocyclic compounds. In fact, in one capacity or another these versatile molecules have influenced nearly all disciplines in chemistry. In recent years, efforts are underway to develop tetrahydroporphyrin-based (bacteriochlorin) compounds with long wavelength absorption in the range of 700-800 nm as photosensitizers for photodynamic therapy (PDT). This review article summarizes the synthetic methodologies that have been developed for the preparation of a variety of bacteriochlorins, either from porphyrins or chlorin systems.
Export Options
About this article
Cite this article as:
Chen Yihui, Li Guolin and Pandey K. Ravindra, Synthesis of Bacteriochlorins and Their Potential Utility in Photodynamic Therapy (PDT), Current Organic Chemistry 2004; 8 (12) . https://dx.doi.org/10.2174/1385272043370131
DOI https://dx.doi.org/10.2174/1385272043370131 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Regulation by IFN-α/IFN-γ Co-Formulation (HerberPAG<sup>®</sup>) of Genes Involved in Interferon-STAT-Pathways and Apoptosis in U87MG
Current Topics in Medicinal Chemistry Notch Signaling: A Potential Therapeutic Target in Prostate Cancer
Current Cancer Drug Targets Ribonucleases and ImmunoRNases as Anticancer Drugs
Current Pharmaceutical Design Subject Index To Volume 1
Current Bioinformatics Survey of Functional Activities of Alpha-fetoprotein Derived Growth Inhibitory Peptides: Review and Prospects
Current Protein & Peptide Science Exploiting APC Function as a Novel Cancer Therapy
Current Drug Targets Ceramide in Chemotherapy of Tumors
Recent Patents on Anti-Cancer Drug Discovery Exploring Single Nucleotide Polymorphisms in ITGAV for Gastric, Pancreatic and Liver Malignancies: An Approach Towards the Discovery of Biomarker
Combinatorial Chemistry & High Throughput Screening Bacteriochlorophyll a and Its Derivatives: Chemistry and Perspectives for Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Organocatalysis in the Synthesis of Natural Products: Recent Developments in Aldol and Mannich Reactions, and 1,4-Conjugated Additions
Current Organocatalysis Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases
Current Reviews in Clinical and Experimental Pharmacology Zinc, Metallothioneins and Longevity: Interrelationships with Niacin and Selenium
Current Pharmaceutical Design Personalized Diabetes and Cancer Medicine: A Rationale for Anti-Diabetic Nutrition (Bitter Melon) in a Supportive Setting
Current Cancer Therapy Reviews Roles of miRNA in the Initiation and Development of Colorectal Carcinoma
Current Pharmaceutical Design The Immunoproteasome: An Emerging Therapeutic Target
Current Topics in Medicinal Chemistry Role of Nitric Oxide in the Modulation of Angiogenesis
Current Pharmaceutical Design Integrated, Molecular Engineering Approaches to Develop Prostate Cancer Gene Therapy
Current Gene Therapy (Phospho)lipid-based Nanosystems for Skin Administration
Current Pharmaceutical Design Heterologous Virus-Like-Particles: Recombinant Nanosystems as Versatile Antigen Delivery Devices for Immune Intervention
Current Nanoscience NGS of microRNAs Involved in Cardioprotection Induced by Sevoflurane Compared to Propofol in Myocardial Revascularization Surgery: The ACDHUVV-16 Clinical Trial
Current Medicinal Chemistry