摘要
背景:在过去几年中,由于这种系统的明显医疗益处,智能触发的受控药物输送中的释放已经达到了科学界的惊人的兴趣。代表。非全身性给药引起的毒性降低并不是唯一的原因,虽然这是一个主要的原因,通常是在抗癌治疗中,但是。。。另外,一些好的治疗物质由于其高疏水性或由于在所需的输送地点的吸收很差而不能使用。 目的:本综述旨在突出科学界为更有效地触发目的地的药物有效载荷而作出的努力,从而避免系统性的暴露。对药物的毒性作用。 结果:本文对几种触发因素进行了评估,包括pH触发传递、热触发传递、氧化还原改变触发传递以及对tr的修改。依格在特定的位置上基于受体对某种化学成分的亲和力,如叶酸。 结论:通过适当的纳米制剂,系统传递策略所遇到的障碍可以被克服,而疏水药物可以通过一些小的改变通过。对它们的结构进行了微小的修改,同时确保治疗形式被人体自身的内部系统破坏。触发给药的主要优点是:更好的医疗保健策略和局部分娩,在这个案例中获胜的主要人是病人,应该始终是医疗系统的核心。
关键词: 磁性纳米颗粒,药物释放,磁共振成像,触发释放,pH触发传递,热触发传递。
图形摘要
Current Drug Targets
Title:Smart Triggered Release in Controlled Drug Delivery
Volume: 19 Issue: 4
关键词: 磁性纳米颗粒,药物释放,磁共振成像,触发释放,pH触发传递,热触发传递。
摘要: Background: Smart triggered release in controlled drug delivery has met an astonishing interest from the scientific community in the past few years due to the obvious medical benefits this type of systems represents. The reduction in toxicity due to a non-systemic administration is not the only reason for this increase, although it is a major reason for concern typically in anti-cancer therapy, but also the fact that some good therapeutic substances cannot be used either due to their high hydrophobicity or due to a very poor absorption at the required site of delivery.
Objective: This review article aims to highlight the efforts made by the scientific community in order to more efficiently trigger the drug payload at its destination, thus avoiding systemic exposure to the drug's toxic effect.
Results: In this review article several types of triggers have been evaluated, pH triggered delivery, thermally triggered delivery, REDOX change triggered delivery, as well as modifications made to trigger at a specific location based on the affinity of the receptors for a certain chemical moiety, such as folic acid.
Conclusions: Through a proper nano-formulation the obstacles encountered by systemic delivery strategies can be circumvented, and through minor modifications hydrophobic drugs can be delivered through minor modifications to their structure, ensuring in the meantime that the therapeutic form is broken down by the human body’s own internal systems. The main advantages in triggered drug delivery are the better healthcare strategy and the topical delivery, the main person winning in this case being the patient, the one person that should always be at the heart of the medical system.
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Cite this article as:
Smart Triggered Release in Controlled Drug Delivery, Current Drug Targets 2018; 19 (4) . https://dx.doi.org/10.2174/1389450117666160401125034
DOI https://dx.doi.org/10.2174/1389450117666160401125034 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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