摘要
肥胖和抑郁症的患病率日益增加,在世界各地都成为一个重要的健康问题。有研究表明,肥胖和抑郁症之间的存在积极和双向的关联。中枢神经系统与饱感信号和高度情绪的启发有关。增加血清素神经传递的药物通常用于治疗抑郁症。但许多患者并不能被这些药物治愈,同时缓解的效果也不是很理想。作为减肥药物的血清素已经被从市场上撤回或被拒绝长期使用。寻找肥胖和抑郁症的新的治疗靶点十分关键,瘦素的作用也变得越来越重要。由脂肪细胞分泌的肽激素能通过其受体透过血脑屏障在下丘脑引起饱感信号。新的证据表明,肽激素在应激反应中发挥作用,并产生抗抑郁样作用。另一方面,肥胖和抑郁症往往与高水平的瘦素水平有关,这表明其对瘦素并不敏感。本文旨在探索研究瘦素抵抗的机制。这些研究可能有助于开发替代5-羟色胺为基础的药物治疗方法,达到治疗肥胖抑郁症的目的。
关键词: 肥胖,抑郁症,5-羟色胺,瘦素
图形摘要
Current Drug Targets
Title:Drug Targets for Obesity and Depression: From Serotonin to Leptin
Volume: 17 Issue: 11
Author(s): Darakhshan Jabeen Haleem
Affiliation:
关键词: 肥胖,抑郁症,5-羟色胺,瘦素
摘要: The increasing prevalence of both obesity and depression is becoming a significant health concern throughout the world. Evidence suggests a positive and bidirectional association between obesity and depression. It is now well established that central serotonergic system is involved in the elicitation of satiety signal and elevation of mood. Drugs that increase serotonin neurotransmission are commonly recommended for the treatment of depression. But many patients are not benefitted by these drugs, while remission rate is also not satisfactory. Serotonin based antiobesity drugs have been either withdrawn from the market or disapproved for long term use. In view of critical need for novel therapeutic targets for obesity and depression, the role of leptin is becoming increasingly important. The peptide hormone secreted by adipocytes can cross blood brain barriers to elicit satiety signal via its receptors in the hypothalamus. Emerging evidence suggests that the peptide hormone has a role in responses to stress and produces antidepressant like effects. On the other hand, both obesity and depression are often associated with higher levels of leptin in circulation suggesting insensitivity to leptin. The aim of the present article is to draw research interest towards exploring mechanism involved in leptin resistance. These studies may facilitate the development of alternative treatment strategies, beyond serotonin based drugs, for obesity depression and their comorbid condition.
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Cite this article as:
Darakhshan Jabeen Haleem , Drug Targets for Obesity and Depression: From Serotonin to Leptin, Current Drug Targets 2016; 17 (11) . https://dx.doi.org/10.2174/1389450117666151209123049
DOI https://dx.doi.org/10.2174/1389450117666151209123049 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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