摘要
动脉粥样硬化是由炎症引起的先天性适应性免疫反应疾病。Toll样受体是免疫系统模式明确的识别受体,它巨噬细胞的活化中发挥核心作用。Toll样受体识别由感染剂引发的病原体相关的分子模式,并提供了本地先天免疫和适应性免疫之间的联系。这些受体的激活触发细胞内通过髓样分化因子88或toll/interleukin-1 receptor-domain-containing adapter-inducing interferon-β介导的信号级联,导致抗炎细胞因子的分泌。Toll样受体与他们的配位体诱导白细胞募集和增强基质金属蛋白酶在动脉粥样硬化病变中的表达。最近研究表明,某些样受体在动脉粥样硬化中起到保护作用。因此,Toll样受体是炎症和动脉粥样硬化之间的一个重要环节,这可能成为动脉粥样硬化治疗的新靶点。本文描述了作为治疗动脉粥样硬化治疗靶点的Toll样受体的生物结构和潜在作用。
关键词: Toll-like receptor
Current Medicinal Chemistry
Title:Essential Roles of Toll-Like Receptors in Atherosclerosis
Volume: 23 Issue: 5
Author(s): Juntang Lin, Vijay Kakkar and Xinjie Lu
Affiliation:
关键词: Toll-like receptor
摘要: Atherosclerosis is driven by inflammation with an involvement of innate and adaptive immune responses. Toll-like receptors, the well-defined pattern recognition receptors of the immune system, play a central role in macrophage activation. Toll-like receptors recognize pathogen-associated molecular patterns expressed by a wide range of infectious agents and provide a strong link between local innate and adaptive immunity. Activation of these receptors triggers an intracellular signaling cascade mediated through myeloid differentiation factor 88 or toll/interleukin-1 receptor-domain-containing adapter-inducing interferon-β, leading to the secretion of proand anti-inflammatory cytokines. Engagement of Toll-like receptors with their ligands induces leukocyte recruitment and enhances matrix metalloproteinase expression within atherosclerotic lesions. Recently certain Toll-like receptors have shown a protective role in atherosclerosis. TLRs, therefore, represent an important link between inflammation and atheroma, making them attractive targets for the treatment of atherosclerosis. This review will briefly describe the general biological structure and potential roles of Toll-like receptors as therapeutic targets for the treatment of atherosclerosis and highlight the potential challenges on Toll-like receptor- based therapy in cardiovascular disease.
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Cite this article as:
Juntang Lin, Vijay Kakkar and Xinjie Lu , Essential Roles of Toll-Like Receptors in Atherosclerosis, Current Medicinal Chemistry 2016; 23 (5) . https://dx.doi.org/10.2174/0929867323666151207111408
DOI https://dx.doi.org/10.2174/0929867323666151207111408 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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