Abstract
Background: Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT, is a well-studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy. Nattokinase is witnessed to be a useful enzyme for the complete removal of the vitreous and associated proliferative tissues in proliferative vitreo retinal disorders.
Conclusion: This review focuses on the native and recombinant Nattokinase from bacteria and other sources, their production, purification, immobilization and nano-immobilization studies, which aid in ameliorating their properties to suit the targeted industrial applications. Recent development in these fields are presented and discussed, and prospective developments are suggested.
Keywords: Cardiovascular disease, nano immobilization, fibrinolytic enzymes, recombinant Nattokinase, hypertention, myocardial infarction.
Graphical Abstract
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