摘要
纳米颗粒(纳米)的应用为结直肠癌的早期发现和有效治疗提供了新的前景。各种纳米颗粒已被设计和探讨作为诊断和或治疗药物输送载体。为了实现选择性治疗和减少毒性,这些纳米粒子通常被赋予靶向的能力。被动靶向基于渗透和增强肿瘤的渗透和滞留效应,而主动靶向性总是涉及到与结直肠癌组织中,可识别的特异性配体,如血管内皮生长因子、叶酸、单克隆抗体(mAbs)、适体和穿膜肽。此外,造影剂,如钆配合物和氧化铁颗粒,可以引入到给药系统,使能磁共振成像和病变检测。此外,智能载体已逐渐应用到给药系统。这些载体的设计满足应对在生物环境中的某些变化,并释放封装的内容物的需求,从而实现在肿瘤部位有有效的药物浓度。本文着重于NP靶向诊断和治疗结直肠癌的技术进展,旨在揭示利用纳米载体增强治疗应用的新兴的可能性。
关键词: 结肠直肠癌靶向;给药;磁共振成像;主动控制
图形摘要
Current Cancer Drug Targets
Title:Nanoparticles for Colorectal Cancer Targeted Drug Delivery and MR Imaging: Current Situation and Perspectives
Volume: 16 Issue: 6
Author(s): Zhi Dong, Min-Yi Cui, Zhenpeng Peng, Yin Li, Xiaoling Wang, Zhuangnian Fang, Mengjie Jiang, Ling Xu, Yanji Luo, Zi-Ping Li and Shi-Ting Feng
Affiliation:
关键词: 结肠直肠癌靶向;给药;磁共振成像;主动控制
摘要: The application of nanoparticles (NPs) offers new prospects for the early detection and effective therapy of colorectal cancer (CRC). Various NPs have been designed and explored as diagnostic and/or therapeutic drug delivery vehicles. To achieve selective treatment and to reduce toxicity, these nanoparticles are usually endowed with targeting abilities. Passive targeting is based on the extravasation and enhanced permeability and retention effect of tumors, while active targeting always involves binding to specific ligands that are recognizable by CRC tissues, such as vascular endothelial growth factor, folate, monoclonal antibodies (mAbs), aptamers, and membrane penetrating peptides. In addition, contrast agents, such as gadolinium complexes and iron oxide particles, can be introduced into the delivery system to enable MR imaging and lesion detection. Furthermore, smart carriers have been gradually applied to the delivery system. These carriers are designed to respond to certain changes in the bio-environment and release encapsulated contents on demand, thus achieving effective drug concentrations at tumor sites. This review focuses on recent advances of NP technology for the targeted diagnosis and treatment of CRC and aims to unveil the emerging possibilities of using nanocarriers to enhance therapeutic applications.
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Zhi Dong, Min-Yi Cui, Zhenpeng Peng, Yin Li, Xiaoling Wang, Zhuangnian Fang, Mengjie Jiang, Ling Xu, Yanji Luo, Zi-Ping Li and Shi-Ting Feng , Nanoparticles for Colorectal Cancer Targeted Drug Delivery and MR Imaging: Current Situation and Perspectives, Current Cancer Drug Targets 2016; 16 (6) . https://dx.doi.org/10.2174/1568009616666151130214442
DOI https://dx.doi.org/10.2174/1568009616666151130214442 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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