摘要
造成癌症病人死亡的主要因素转移是一种包含一些连续的,相关的和高选择性步骤的复杂过程。生长诱导因子14是肿瘤坏死因子受体家族因素的一个成分。它在控制细胞分裂,生存和死亡中有影响。Fn 14 在肿瘤转移作用的规律在慢慢被揭开,包括上皮间质转化,血管再生,细胞骨架调制,细胞外基质降解和炎症的作用规律。这篇综述将集中研究最近FN14在肿瘤发展中的报道,并简要介绍FN14调控转移的各种途径。最后,讨论FN14作为预测标志物和肿瘤转移抑制的治疗剂的潜在作用的未来前景
关键词: Fn 14, 癌症, 转移, 靶向治疗, 信号通路
Current Molecular Medicine
Title:Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis
Volume: 15 Issue: 10
Author(s): X. Wang, Y. Zeng, D. N. Ho, J. Yin, G. Liu and X. Chen
Affiliation:
关键词: Fn 14, 癌症, 转移, 靶向治疗, 信号通路
摘要: Metastasis, the main cause of mortality in cancer patients, is a complex process consisting of several sequential, interlinked, and highly-selective steps. Fibroblast growth factor-inducible 14 (Fn14) is one member of the tumor necrosis factor receptor family, which is influential in controlling cell division, life, and death. The role of Fn14 in tumor metastasis regulation is slowly being unraveled, including roles in the regulation of the epithelial-mesenchymal transition, angiogenesis, cytoskeleton modulation, extracellular matrix degradation and inflammation. This review will focus on recent studies that demonstrate the involvement of Fn14 in tumor progression and will briefly describe various pathways of Fn14-regulated metastasis. Finally, future prospects will be discussed for the potential role of Fn14 as a predictive marker and therapeutic agent for tumor metastasis suppression.
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Cite this article as:
X. Wang, Y. Zeng, D. N. Ho, J. Yin, G. Liu and X. Chen , Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis, Current Molecular Medicine 2015; 15 (10) . https://dx.doi.org/10.2174/1566524016666151123105752
DOI https://dx.doi.org/10.2174/1566524016666151123105752 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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