摘要
阿尔茨海默病(AD)是一种以渐进性认知能力损害为标志的神经退行性疾病 。AD显示的病理病变病人包括有斑块的患者,神经纤维缠结,以及认知功能的脑区神经元丢失。尽管进展中发现了许多因素有助于了解疾病的病因,但神经元的死亡在很大程度上是未知的。炎症似乎在AD的发病过程中发挥了重要作用,脑内炎性过程主要是由星形胶质细胞,小胶质细胞,细胞因子,趋化因子和生长因子的信号转导分子固有免疫系统所介导的。然而,越来越多的证据表明中枢神经系统(CNS)与从血液流的淋巴细胞和单核细胞有关联,暗示免疫和免疫系统之间有一个强烈的串扰。另一方面,一些特定的AD脑源性蛋白质或代谢产物可通过血脑屏障进入血浆,并在外周细胞中发挥一些可测量的信号物质。本次审查的目标是:1)探索信号通路的变化证据,它们能调节阿尔兹海默病中枢和外周的改变,2)探索免疫细胞中尤其是淋巴细胞的改变是否导致了AD的发病。
关键词: 阿尔茨海默病;细胞凋亡;淋巴细胞;细胞周期;线粒体功能障碍;蛋白酶体;信号途径。
Current Alzheimer Research
Title:Lymphocytes in Alzheimer’s Disease Pathology: Altered Signaling Pathways
Volume: 13 Issue: 4
Author(s): Noemi Esteras, Carolina Alquezar, Ana de la Encarnacion, Angeles Martin-Requero
Affiliation:
关键词: 阿尔茨海默病;细胞凋亡;淋巴细胞;细胞周期;线粒体功能障碍;蛋白酶体;信号途径。
摘要: Alzheimer’s disease (AD) is a neurodegenerative disorder marked by progressive impairment of cognitive ability. Patients with AD display neuropathological lesions including plaques, neurofibrillary tangles, and neuronal loss in brain regions linked to cognitive functions. Despite progress in uncovering many of the factors that contribute to the etiology of this disease, the cause of neuronal death is largely unknown. Neuroinflammation seems to play a critical role in the pathogenesis of AD. Inflammatory processes in the brain are mainly mediated by the intrinsic innate immune system consisting of astrocytes and microglial cells, and cytokine, chemokine, and growth factor signaling molecules. However mounting evidence suggest that the Central Nervous System (CNS) is accessible to lymphocytes and monocytes from the blood stream, indicating that there is an intense crosstalk between the immune and the CN systems. On the other hand, some AD-specific brain-derived proteins or metabolites may enter the plasma through a deficient blood-brain barrier, and exert some measurable signaling properties in peripheral cells. The goals of this review are: 1) to explore the evidences of changes in signaling pathways that could mediate both central and peripheral manifestations of AD, and 2) to explore whether changes in immune cells, particularly lymphocytes, could contribute to AD pathogenesis.
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Cite this article as:
Noemi Esteras, Carolina Alquezar, Ana de la Encarnacion, Angeles Martin-Requero , Lymphocytes in Alzheimer’s Disease Pathology: Altered Signaling Pathways, Current Alzheimer Research 2016; 13 (4) . https://dx.doi.org/10.2174/1567205013666151116124912
DOI https://dx.doi.org/10.2174/1567205013666151116124912 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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