摘要
在泛素化系统中,E3泛素连接酶在确定的底物特异性和催化泛素E2酶转移到底物中发挥关键作用。越来越多的证据表明,E3泛素连接酶参与癌症的发生和发展。环式和HECT类E3连接酶的经典分类组的E3泛素连接酶,和更多的这些酶被证明是癌症治疗的潜在目标。最近分类的RBR泛素E3连接酶促进了由环/ HECT混合样机制作用的泛素转移。值得注意的是,这些连接酶被强调为重要潜在的作为癌症治疗药物的可选目标。本文综述了RING结构域家族、HECT结构域家族和RBR型E3连接酶,并探讨其在肿瘤中的作用与肿瘤治疗。
关键词: 癌症,HECT结构域家族,E3泛素连接酶,RBR,RING结构域家族,泛素
Current Cancer Drug Targets
Title:RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer
Volume: 16 Issue: 2
Author(s): Chiharu Uchida and Masatoshi Kitagawa
Affiliation:
关键词: 癌症,HECT结构域家族,E3泛素连接酶,RBR,RING结构域家族,泛素
摘要: In the ubiquitylation system, E3 ubiquitin ligases play a key role in determining substrate specificity and catalyzing the transfer of ubiquitin from E2 enzymes to the substrate. Growing evidence has shown that E3 ubiquitin ligases are involved in cancer development and progression. The RING-type and HECT-type E3 ligases are the classically categorized groups of E3 ubiquitin ligases, and more of these enzymes are being shown to be potential targets for cancer therapy. The recently classified RBR E3 ligases catalyze the transfer of ubiquitin by a RING/HECT hybrid-like mechanism. Notably, these ligases are also emphasized as important potential candidates for targets of cancer treatment drugs. The present review provides an overview of the RING-, HECT- and RBR-type E3 ligases, and discusses their roles in cancer and cancer therapy.
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Chiharu Uchida and Masatoshi Kitagawa , RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer, Current Cancer Drug Targets 2016; 16 (2) . https://dx.doi.org/10.2174/1568009616666151112122801
DOI https://dx.doi.org/10.2174/1568009616666151112122801 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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