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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Review Article

p42.3 in Gastric Carcinoma: A Novel Biomarker and Promising Therapeutic Target

Author(s): Hui Jing, Lu-Lu Wei, Fu-Chun Huo, Xin Ren, Jun-Nian Zheng* and Dong-Sheng Pei*

Volume 14, Issue 10, 2017

Page: [1221 - 1225] Pages: 5

DOI: 10.2174/1570180814666170306121357

Price: $65

Abstract

Objective: To explore the function of p42.3 in gastric carcinoma.

Methods: We summarized the intricate regulation of p42.3 in gastric carcinoma from several aspects, namely, the structure features, the expression level, its regulation on cell cycle and EMT, its relationship with miR-29a as well as the optimal feedback circuit involved in.

Results: We addressed the complex functions of p42.3 in regulating EMT, migration, invasion, proliferation and the optimal regulation network in GC, as well as the significant up/down-stream signal molecules involved in the pathway. We have also illuminated that miR-29a can inhibit cell proliferation and block the cell cycle, at least in part, via the repression of p42.3.

Conclusion: In short, p42.3 might serve as a potential therapeutic target in the treatment of GC.

Keywords: p42.3, gastric carcinoma, cell cycle, EMT, miR-29a, therapeutic target.

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