Abstract
Alterations in myocardial metabolism and blood flow have been described in patients with metabolic disorders, cardiovascular disease and cardiomyopathies, and have been implicated in the pathogenesis or prognosis of cardiac conditions. Adipose tissue dysfunction occurs in the above categories of patients. Adipose tissue plays a fundamental role in the modulation and selection of nutrients reaching the myocardium, and adipocytes secrete adipokines and other molecules affecting myocardial metabolism and regulating vascular function. In turn, the myocardium secretes a series of peptides affecting adipose tissue metabolism, and adipose tissue vascularization and perfusion contribute to the maintenance of adipose tissue health. This review addresses the reciprocal interaction linking adipose tissue to myocardial metabolism and vascular function. We summarize evidence of factors released by adipose tissue that affect cardiac metabolism and vice versa. Then, we address the role of adipose tissue in regulating vascular health, and examine whether adipose tissue hypoperfusion is causative or defensive of adipose tissue dysfunction.
Keywords: Fatty acids, natriuretic peptides, hypoxia, adiponectin, obesity, cardiovascular disease.
Current Pharmaceutical Design
Title:Cross-Talk Between Adipose Tissue Health, Myocardial Metabolism and Vascular Function: The Adipose-Myocardial and Adipose-Vascular Axes
Volume: 22 Issue: 1
Author(s): Patricia Iozzo and Maria Angela Guzzardi
Affiliation:
Keywords: Fatty acids, natriuretic peptides, hypoxia, adiponectin, obesity, cardiovascular disease.
Abstract: Alterations in myocardial metabolism and blood flow have been described in patients with metabolic disorders, cardiovascular disease and cardiomyopathies, and have been implicated in the pathogenesis or prognosis of cardiac conditions. Adipose tissue dysfunction occurs in the above categories of patients. Adipose tissue plays a fundamental role in the modulation and selection of nutrients reaching the myocardium, and adipocytes secrete adipokines and other molecules affecting myocardial metabolism and regulating vascular function. In turn, the myocardium secretes a series of peptides affecting adipose tissue metabolism, and adipose tissue vascularization and perfusion contribute to the maintenance of adipose tissue health. This review addresses the reciprocal interaction linking adipose tissue to myocardial metabolism and vascular function. We summarize evidence of factors released by adipose tissue that affect cardiac metabolism and vice versa. Then, we address the role of adipose tissue in regulating vascular health, and examine whether adipose tissue hypoperfusion is causative or defensive of adipose tissue dysfunction.
Export Options
About this article
Cite this article as:
Iozzo Patricia and Angela Guzzardi Maria, Cross-Talk Between Adipose Tissue Health, Myocardial Metabolism and Vascular Function: The Adipose-Myocardial and Adipose-Vascular Axes, Current Pharmaceutical Design 2016; 22 (1) . https://dx.doi.org/10.2174/1381612822666151109111834
DOI https://dx.doi.org/10.2174/1381612822666151109111834 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mineralocorticoid Receptor Antagonism and Cardiac Remodeling in Ischemic Heart Failure
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Circulating Endothelial Progenitor Cells Characterization, Function and Relationship with Cardiovascular Risk Factors
Current Pharmaceutical Design Rho Kinase Inhibitors: Potential Treatments for Diabetes and Diabetic Complications
Current Pharmaceutical Design Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy
Endocrine, Metabolic & Immune Disorders - Drug Targets The Use of Anthracyclines for Therapy of CNS Tumors
Anti-Cancer Agents in Medicinal Chemistry The Impact of Traditional Chinese Medicine on Mitophagy in Disease Models
Current Pharmaceutical Design Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models
Current Neuropharmacology Pleiotropic Effects of Statin in Therapy in Heart Failure: A Review
Current Vascular Pharmacology Platelet and Soluble Glycoprotein VI - Novel Applications in Diagnosis and Therapy
Current Drug Targets Lipoproteins, Stroke and Statins
Current Vascular Pharmacology Melatonin Regulates Angiogenic and Inflammatory Proteins in MDA-MB-231 Cell Line and in Co-culture with Cancer-associated Fibroblasts
Anti-Cancer Agents in Medicinal Chemistry Diabetic Cardiomyopathy: Clinical and Metabolic Approach
Current Vascular Pharmacology Matrix Metalloproteinases: Drug Targets for Myocardial Infarction
Current Drug Targets Targeting Mitochondrial Oxidative Stress Through Lipoic Acid Synthase: A Novel Strategy to Manage Diabetic Cardiovascular Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets
Current Pharmaceutical Design Non-Infectious Complications of Immunosuppressant Medications in Renal Transplant Patients
Current Clinical Pharmacology "Heart Failure: Meeting the Challenges of Surveillance and Knowledge Translation in Resource-poor Settings"
Current Cardiology Reviews Pharmacogenomic Considerations in the Treatment of the Pediatric Cardiomyopathy Called Barth Syndrome
Recent Patents on Biotechnology Cell Sheet-Based Myocardial Tissue Engineering: New Hope for Damaged Heart Rescue
Current Pharmaceutical Design Cardiac Metabolism in Diabetes Mellitus
Current Pharmaceutical Design