Role of Calcium in Platelet Activation: Novel Insights and Pharmacological Implications

Title:Role of Calcium in Platelet Activation: Novel Insights and Pharmacological Implications

Volume: 12 Issue: 2

Author(s): Periklis Davlouros, Ioanna Xanthopoulou, Nikolaos Mparampoutis, Georgios Giannopoulos, Spyridon Deftereos and Dimitrios Alexopoulos

Affiliation:

Keywords: Platelets, activation, calcium, kinetics.

Abstract: Platelets are involved in haemostasis and vessel integrity under physiologic conditions, and in thrombosis under disease states. Platelet activation upon stimulation with various agonists in vitro and in vivo, is strongly dependent on an increase of intracellular Ca²⁺ concentration. The latter results from Ca²⁺ release by the dense tubular system (DTS), and Ca²⁺ entry from the extracellular space. Recent advances in identification of the molecular mechanisms involved in these processes are described in this review, along with potential targets for pharmacologic interventions in disease states.

Cite this article as:

Davlouros Periklis, Xanthopoulou Ioanna, Mparampoutis Nikolaos, Giannopoulos Georgios, Deftereos Spyridon and Alexopoulos Dimitrios, Role of Calcium in Platelet Activation: Novel Insights and Pharmacological Implications, Medicinal Chemistry 2016; 12 (2) . https://dx.doi.org/10.2174/157340641202160208195923