摘要
流行病学研究认为肥胖与哮喘的发病有关,特别是肥胖儿童,这表明肥胖是诱发哮喘的危险因素。肥胖引起的慢性炎症与肺部炎症联系密切,但其作用介质和机理并不明确。肥胖与5-脂氧合酶(5-LO)途径的表达增强有关,在肥胖性哮喘患者中可以观察到白三烯(LTS)生成含量增加。然而,诱发肥胖人群肺部炎症的确切机制并不十分清楚。本文讨论了白三烯(LTS)在肥胖个体中的产生和调控机制以及提出了LTS对导致肥胖性哮喘的肺部炎症的作用机制。白三烯是众所周知的哮喘介质,但在肥胖性哮喘中的作用机理尚不清楚,因此亟待进一步的研究。由于有效的拮抗剂和5-LO通路抑制剂是已知的,对其分子机制特别是半胱氨酰白三烯的认识可以为肥胖个体哮喘提供最佳的预防和治疗方案。
关键词: 脂肪因子,哮喘,半胱氨酰白三烯,肺部炎症,肥胖。
Current Molecular Medicine
Title:Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma
Volume: 15 Issue: 7
Author(s): U.C.S. Yadav and S.K. Srivastava
Affiliation:
关键词: 脂肪因子,哮喘,半胱氨酰白三烯,肺部炎症,肥胖。
摘要: Epidemiological studies associate obesity with onset of asthma, especially in obese children, suggesting obesity as the risk factor for asthma. Obesity-induced chronic inflammation has been implicated in the lung inflammation, yet specific mediators and mechanisms are lacking. Obesity is associated with increased expression of 5-lipoxygenase (5-LO) pathway and increased Leukotrienes (LTs) production has been observed in obese asthma patients. However, the precise mechanism that predisposes lungs inflammation in obese is not clearly understood. This article discusses the production and regulation of LTs in obese individuals and presents probable mechanisms regarding the role of LTs in lung inflammation that may lead to obesity-induced asthma. Leukotrienes are well known mediators of asthma but their role in obesity-induced asthma is not clearly understood and thus needs further research. Since efficient antagonists and inhibitors of 5-LO pathways are known, understanding of molecular mechanism of LTs, especially Cysteinyl-LTs, in obesity-induced asthma could lead to optimal treatment regimens for the prevention and treatment of asthma in obese individuals.
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Cite this article as:
U.C.S. Yadav and S.K. Srivastava , Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma, Current Molecular Medicine 2015; 15 (7) . https://dx.doi.org/10.2174/1566524015666150831130954
DOI https://dx.doi.org/10.2174/1566524015666150831130954 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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