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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety

Author(s): Seref Demirayak, Ismail Kayagil, Leyla Yurttas and Sevda Er

Volume 13, Issue 2, 2016

Page: [178 - 184] Pages: 7

DOI: 10.2174/1570180812666150723001545

Price: $65

Abstract

A series of new N’-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (1- 16) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two nonpathogen microorganisms. The target compounds were obtained with a multi-step reaction starting from 4- substitutedarylhydrazine derivatives and the structures of final compounds have been elucidated with IR, NMR, Mass spectroscopy data and elemental analysis results. The antifungal activity of the compounds was determined against eleven different Fusarium, Trichoderma, Aspergillus and Penicilliumspeciesby using microdilution method. Most of the target compounds showed excellent antifungal activity against a variety of fungal pathogens.

Keywords: Salicylidene hydrazide, 1, 2, 4-triazole, antifungal activity.

Graphical Abstract


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