摘要
癌症的发展主要是由于细胞死亡的解除管制癌细胞抗凋亡通过Bcl-2家族抗凋亡蛋白的表达增加。Mcl-1是一种抗凋亡蛋白,其主要负责癌细胞阻力,因为它在大多数癌细胞类型中过度表达。许多研究项目的目标是通过靶向抗凋亡蛋白天然药理支架,以抑制其在癌症发展的效果,恢复癌细胞死亡。本文主要介绍了Bcl-2蛋白的天然化合物抑制剂,重点在MCL-1。
关键词: 细胞凋亡,癌症,Mcl-1,天然化合物
Current Medicinal Chemistry
Title:Effects of Natural Products on Mcl-1 Expression and Function
Volume: 22 Issue: 30
Author(s): Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato and Marc Diederich
Affiliation:
关键词: 细胞凋亡,癌症,Mcl-1,天然化合物
摘要: Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.
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Cite this article as:
Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato and Marc Diederich , Effects of Natural Products on Mcl-1 Expression and Function, Current Medicinal Chemistry 2015; 22 (30) . https://dx.doi.org/10.2174/0929867322666150716115435
DOI https://dx.doi.org/10.2174/0929867322666150716115435 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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