摘要
癌症的发展主要是由于细胞死亡的解除管制癌细胞抗凋亡通过Bcl-2家族抗凋亡蛋白的表达增加。Mcl-1是一种抗凋亡蛋白,其主要负责癌细胞阻力,因为它在大多数癌细胞类型中过度表达。许多研究项目的目标是通过靶向抗凋亡蛋白天然药理支架,以抑制其在癌症发展的效果,恢复癌细胞死亡。本文主要介绍了Bcl-2蛋白的天然化合物抑制剂,重点在MCL-1。
关键词: 细胞凋亡,癌症,Mcl-1,天然化合物
Current Medicinal Chemistry
Title:Effects of Natural Products on Mcl-1 Expression and Function
Volume: 22 Issue: 30
Author(s): Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato and Marc Diederich
Affiliation:
关键词: 细胞凋亡,癌症,Mcl-1,天然化合物
摘要: Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.
Export Options
About this article
Cite this article as:
Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato and Marc Diederich , Effects of Natural Products on Mcl-1 Expression and Function, Current Medicinal Chemistry 2015; 22 (30) . https://dx.doi.org/10.2174/0929867322666150716115435
DOI https://dx.doi.org/10.2174/0929867322666150716115435 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Thymidine Phosphorylase in Biomodulation of Fluoropyrimidines
Current Pharmaceutical Biotechnology Prevalence and Distribution of Human Papillomavirus Genotype in South Eastern Italy, in the Period 2006-2011: Implications for Intervention
Current Pharmaceutical Design A Facile “Click Chemistry” Approach to Novel Flavonol Glycoconjugates and Their Cytotoxic Activity
Letters in Organic Chemistry Targeting the Mannose Receptor with Mannosylated Subunit Vaccines
Current Medicinal Chemistry Tamoxifen and its New Derivatives in Cancer Research
Recent Patents on Anti-Cancer Drug Discovery Recent Advances of Metal Binding Protein Lactoferrin as an Anti- Microbial Agent
Current Bioactive Compounds Promoting Well-being and Resilience in Employing a Relationship Centered Approach: A Case Study of a Pre-adolescent Boy
Adolescent Psychiatry Pitavastatin and 4-Hydroxy-3-Methoxyacetophenone (HMAP) Reduce Cognitive Dysfunction in Vascular Dementia During Experimental Diabetes
Current Neurovascular Research Phytochemical Screening, Antiproliferative and Antioxidant Properties of Various Extracts from Endemic Origanum acutidens
Combinatorial Chemistry & High Throughput Screening Intracellular Drug Delivery: Mechanisms for Cell Entry
Current Pharmaceutical Design Nanotechnology, A Tool for Diagnostics and Treatment of Cancer
Current Topics in Medicinal Chemistry Application of dsRNA in Cancer Immunotherapy: Current Status and Future Trends
Anti-Cancer Agents in Medicinal Chemistry Editorial: (Thematic Issue Cancer Immunotherapy: Does an Increasing Arsenal of Tools Point to More Fruitful Avenues for Research?)
Anti-Cancer Agents in Medicinal Chemistry The Balancing Act between Colonisers and Inflammation: T regulatory and TH17 Cells in Mucosal Immunity during Otitis Media
Current Immunology Reviews (Discontinued) Pharmacotherapy for Obesity
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Inhibiting the Enzymes of the Endothelin and Renin-Angiotensin Systems in Cancer
Current Enzyme Inhibition Prevalence of Breast Complaints in Women with Mastopathy in Khorramabad
Current Women`s Health Reviews Chemokine Network in the Nervous System: A New Target for Pain Relief
Current Medicinal Chemistry Quality Survival with Fertility after Gynaecological and other Cancers
Current Women`s Health Reviews VEGF Inhibitors in Cancer Therapy
Current Pharmaceutical Design