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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents

Author(s): Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez, Dieudonne Njamen and Colin Clyne Hudson

Volume 22, Issue 30, 2015

Page: [3434 - 3446] Pages: 13

DOI: 10.2174/0929867322666150729115321

Price: $65

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Abstract

Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.

Keywords: Breast cancer, chemopreventive agents, chemotherapeutic agents, flavonoids.


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