摘要
已报道老年痴呆症率具有种族差异,虽然大多数研究都没有注意精细的测量结果,由于教育或其他人口因素混杂,他们也没有研究出除痴呆症之外的其他成果。在这篇综述中,我们将讨论在社区动脉粥样硬化风险(ARIC)的实验,其用于评估与中风,亚临床型脑梗塞,脑白质,以及认知改变和痴呆相关的风险。研究人群是来自美国四个社区,最初从1987-1989年收集的,并有5人次的观测(大部分是在2011-2013年)共15,792名参与者。我们从ARIC研究提供证据,认为不成比例的血管危险因素至少在一些种族差异中可观察到,但特殊的风险因素,如糖尿病,可能会影响非裔美国人与白人参与者的大脑差异。此外,我们将重点研究在遗传性中风,小血管病变和痴呆中的种族差异。
关键词: 脑MRI,认知,痴呆,流行病学,种族差异。
Current Alzheimer Research
Title:Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience
Volume: 12 Issue: 7
Author(s): Rebecca F. Gottesman, Myriam Fornage, David S. Knopman and Thomas H. Mosley
Affiliation:
关键词: 脑MRI,认知,痴呆,流行病学,种族差异。
摘要: Reported rates of dementia differ by race, although most studies have not focused on carefully measured outcomes, confounding by education or other demographic factors, nor have they studied other outcomes other than dementia. In this review we will discuss the experience in the Atherosclerosis Risk in Communities (ARIC) study evaluating racial disparities relating to stroke, subclinical brain infarction, leukoaraiosis, as well as cognitive change and dementia. ARIC is a biracial cohort of 15,792 participants from four U.S. communities, initially recruited in 1987-1989, and seen at a total of 5 in-person visits (most recently seen in 2011-2013) with annual follow-up phone calls. We will provide evidence from ARIC studies that disproportionate rates of vascular risk factors explain at least some of these observed disparities by race, but particular risk factors, including diabetes, may differentially affect the brain in African-American versus white participants. In addition, we will review some of the disparities by race in studies focusing on the genetics of stroke, small vessel disease, and dementia.
Export Options
About this article
Cite this article as:
Rebecca F. Gottesman, Myriam Fornage, David S. Knopman and Thomas H. Mosley , Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience, Current Alzheimer Research 2015; 12 (7) . https://dx.doi.org/10.2174/1567205012666150701102445
DOI https://dx.doi.org/10.2174/1567205012666150701102445 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer's-Like Disease in Rats
Current Reviews in Clinical and Experimental Pharmacology Cardiovascular Adverse Effects of Anti-Inflammatory Drugs
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Potential Biomarkers for Depression Associated with Coronary Artery Disease: A Critical Review
Current Molecular Medicine Prion Function and Pathophysiology in Non-Mammalian Models
Current Molecular Medicine MicroRNAs and Stem Cells to the Rescue
Current Neurovascular Research JNK Signalling: A Possible Target to Prevent Neurodegeneration
Current Pharmaceutical Design Na+-H+ Exchanger, pH Regulation and Cancer
Recent Patents on Anti-Cancer Drug Discovery Cells of the Macrophage Lineage and their Role in the Pathogenesis of HIV-1 Infection: An Update
Medicinal Chemistry Reviews - Online (Discontinued) The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer
Current Medicinal Chemistry An Update on Drug Interactions with the Herbal Medicine Ginkgo biloba
Current Drug Metabolism Microglial Activation and its Implications in the Brain Diseases
Current Medicinal Chemistry Inflammatory Cyclooxygenase Activity and PGE<sub>2</sub> Signaling in Models of Alzheimer’s Disease
Current Immunology Reviews (Discontinued) Endothelial Dysfunction in the Hypertensive State: Mechanisms of Hypertensive Cardiovascular Complications
Current Hypertension Reviews The Pharmacology of Aminoadamantane Nitrates
Current Alzheimer Research Therapeutic Approaches for Lysosomal Storage Diseases: A Patent Update
Recent Patents on CNS Drug Discovery (Discontinued) Impaired Translation of Spatial Representation in Young Onset Alzheimer’s Disease Patients
Current Alzheimer Research Antiviral Treatment of Cytomegalovirus Infection
Infectious Disorders - Drug Targets Neuroinflammation: Microglial Activation During Sepsis
Current Neurovascular Research Tackling the Elusive Challenges Relevant to Conquering the 100-Plus Year Old Problem of Alzheimer’s Disease
Current Alzheimer Research Conditional Tat Protein Brain Expression in the GT-tg Bigenic Mouse Induces Cerebral Fractional Anisotropy Abnormalities
Current HIV Research