摘要
瘤内给药,可增加肿瘤微环境中药物局部浓度,可能在促进抗肿瘤活性和减少某些药物的全身性副作用方面优于全身给药。但是,并非所有人类癌症适合将药物注射到肿瘤部位。肺癌作为候选肿瘤,采取局部给药的优势,经由支气管内进行气雾给药。气雾给药在肺部疾病治疗中很有前景,是当前哮喘和慢性阻塞性肺疾病的标准治疗方式。除了一个高的局部浓度,气雾剂给药的优点还包括减少药物在全身循环的分布及无痛和无针给药。几种治疗剂已用于吸入性肺恶性肿瘤,包括化疗剂、细胞因子、Toll样受体激动剂、单克隆抗体、基因和反义寡核苷酸,结果表明,气雾剂给药是可行性的,与全身治疗相比,其可提高潜在的抗肿瘤效果并降低副作用。本文总结了这些药物在肺癌治疗中喷雾给药的临床前和临床数据。
关键词: 气雾给药,化疗,细胞因子,基因治疗,肺癌,单克隆抗体,Toll样受体激动剂。
Current Cancer Drug Targets
Title:Aerosol Delivery in the Treatment of Lung Cancer
Volume: 15 Issue: 7
Author(s): Chiara Storti, Valentino Le Noci, Michele Sommariva, Elda Tagliabue, Andrea Balsari and Lucia Sfondrini
Affiliation:
关键词: 气雾给药,化疗,细胞因子,基因治疗,肺癌,单克隆抗体,Toll样受体激动剂。
摘要: Intratumoral delivery of drugs, enabling increased local concentrations in the tumor microenvironment, might be superior to systemic administration in promoting antitumor activity and minimizing the systemic side effects of some drugs. Unfortunately, not all human cancers are amenable to drug injection into the tumor site. Lung cancers are candidate tumors for taking advantage of local delivery, being accessible via the endobronchial space by aerosol administration. Inhalation of aerosolized drugs is a promising option in the management of lung diseases and currently represents the standard treatment for asthma and chronic obstructive pulmonary disease. Besides a high local concentration, the advantages of aerosol administration of medications to the lung include reduced distribution to the systemic circulation and pain- and needle-free delivery. Several therapeutic agents have been explored for inhalation in lung malignancies, including chemotherapeutic agents, cytokines, Toll-like receptor agonists, monoclonal antibodies, genes and antisense oligonucleotides, demonstrating the feasibility of aerosol delivery, the potential antitumor effects and the reduced side effects compared with systemic treatment. In this review we summarize preclinical and clinical data regarding aerosol delivery of these drugs in the treatment of lung cancer.
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Chiara Storti, Valentino Le Noci, Michele Sommariva, Elda Tagliabue, Andrea Balsari and Lucia Sfondrini , Aerosol Delivery in the Treatment of Lung Cancer, Current Cancer Drug Targets 2015; 15 (7) . https://dx.doi.org/10.2174/1568009615666150602143751
DOI https://dx.doi.org/10.2174/1568009615666150602143751 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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