摘要
缺血性心脏病包括由几个风险因素发展和一些疾病如肥胖、糖尿病、高血压和高胆固醇血症伴随的心肌梗死。缺血性心脏病是全球死亡率的主要原因。因此,新药物靶点的识别对心脏保护有重要意义。缺血预处理、后处理和远程调节触发内源性保护机制,使心脏更耐致命局部缺血-再灌注损伤。然而,主要的心血管疾病并发症,如高脂血症、糖尿病和它们的联合用药干扰这些保护机制,从而限制缺血性保护调节的作用 缺血再灌注损伤和心脏保护的调节已经被证明在转录物水平能够影响整个心肌基因表达。进一步的研究,正常心血管基因表达指纹的综合分析、保护调节机制,可能会导致心脏保护的新分子目标的识别。
关键词: 微阵列,微RNA,miRNA,mRNA,后处理,前处理,蛋白质组,风险因素,序列,系统生物学,转录组学
Current Drug Targets
Title:Functional Genomics of Cardioprotection by Ischemic Conditioning and the Influence of Comorbid Conditions: Implications in Target Identification
Volume: 16 Issue: 8
Author(s): Zoltan V. Varga, Zoltan Giricz, Peter Bencsik, Rosalinda Madonna, Mariann Gyongyosi, Rainer Schulz, Manuel Mayr, Thomas Thum, Laszlo G. Puskas and Peter Ferdinandy
Affiliation:
关键词: 微阵列,微RNA,miRNA,mRNA,后处理,前处理,蛋白质组,风险因素,序列,系统生物学,转录组学
摘要: Ischemic heart disease including myocardial infarction develops on the basis of several risk-factors and comorbidities such as obesity, diabetes, hypertension, and hypercholesterolemia. Ischemic heart disease is the leading cause of mortality worldwide, therefore, identification of novel drug targets for cardioprotection is of great importance. Ischemic preconditioning, postconditioning, and remote conditioning trigger endogenous cardioprotective mechanisms that render the heart more resistant to lethal ischemic-reperfusion injury. However, major cardiovascular co-morbidities such as hyperlipidemia, diabetes, and their co-medications interfere with these cardioprotective mechanisms thereby limiting the efficacy of cardioprotective ischemic conditioning maneuvers. Ischemia reperfusion injury and cardioprotection by conditioning have been shown to affect global myocardial gene expression profile at the transcript level. Further understanding and the comprehensive analysis of the cardioprotective gene expression fingerprint in normal, protected, and in comorbid conditions may lead to identification of novel molecular targets for cardioprotection.
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Zoltan V. Varga , Zoltan Giricz , Peter Bencsik , Rosalinda Madonna , Mariann Gyongyosi , Rainer Schulz , Manuel Mayr , Thomas Thum , Laszlo G. Puskas and Peter Ferdinandy , Functional Genomics of Cardioprotection by Ischemic Conditioning and the Influence of Comorbid Conditions: Implications in Target Identification, Current Drug Targets 2015; 16 (8) . https://dx.doi.org/10.2174/1389450116666150427154203
DOI https://dx.doi.org/10.2174/1389450116666150427154203 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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