Structure, DNA Binding and Cytotoxicity Studies of [Cu(D-glu)(phen)(H2O)]•NO3•2H2O

Title:Structure, DNA Binding and Cytotoxicity Studies of [Cu(D-glu)(phen)(H2O)]•NO3•2H2O

Volume: 12 Issue: 8

Author(s): Ling Liu, Jie Mou, Youguang Zheng, Tonghui Huang, Shuaishuai Wang and Yi Liu

Affiliation:

Keywords: [Cu(D-glu)(phen)(H₂O)] • NO₃ • 2H₂O, crystal structure, fluorescence studies, cytotoxic studies.

Abstract: A new complex [Cu(D-glu)(phen)(H₂O)]·NO₃·2H₂O 1 (D-glu = D-glutamic acid, phen = 1,10-phenanthroline) was synthesized and identified by IR spectroscopy and single-crystal X-ray diffraction. Fluorescence studies showed that 1 exhibited stronger intercalative interaction to CT-DNA as compared to known complex [Cu(L-glu)(phen)(H₂O)]·NO₃·2H₂O 2. Both complexes inhibited the growth of MCF-7 cells with the IC₅₀ values of 0.141 μmol·L^-1 and 0.126 μmol·L^-1 for complex 1 and 2, respectively. The complexes were 20 times more active than the amino acid - free complex [Cu(phen)(H₂O)2(NO₃3)] · NO₃ 3.

Cite this article as:

Liu Ling, Mou Jie, Zheng Youguang, Huang Tonghui, Wang Shuaishuai and Liu Yi, Structure, DNA Binding and Cytotoxicity Studies of [Cu(D-glu)(phen)(H2O)]•NO3•2H2O, Letters in Drug Design & Discovery 2015; 12 (8) . https://dx.doi.org/10.2174/1570180812666150213230711

DOI https://dx.doi.org/10.2174/1570180812666150213230711	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X