摘要
炎性肠病(IBD)是一种病因未明的慢性、复发性和缓和性胃肠道(GI)疾病。IBD病人通常显示出肠外临床表现和炎性性质的并发症,呈现出的紊乱如强直性脊柱炎、葡萄膜炎和血管炎。虽然代谢综合症在IBD病人中并不常见,但是他们患动脉粥样硬化和心血管疾病的风险却增加了。相当大的证据支持GI菌群在IBD发展中的作用。近期研究也显示了肠道微生物群代谢和心血管疾病发展之间的重要的相互作用。在此我们假设肠道菌群功能的失调和/或畸形会促进IBD病人的心血管疾病,解释了患心血管疾病的高风险。
关键词: 冠心病,胃肠道炎症,炎性肠病,微生物群,三甲胺
Current Drug Targets
Title:Intestinal Microbiota: A Regulator of Intestinal Inflammation and Cardiac Ischemia?
Volume: 16 Issue: 3
Author(s): Mohammad Bashashati, Hamid R. Habibi, Ali Keshavarzian, Max Schmulson and Keith A. Sharkey
Affiliation:
关键词: 冠心病,胃肠道炎症,炎性肠病,微生物群,三甲胺
摘要: Inflammatory bowel diseases (IBD) are chronic, relapsing and remitting gastrointestinal (GI) disorders of unknown etiology. IBD patients commonly exhibit extra-intestinal manifestations and complications of an inflammatory nature, presenting with disorders such as ankylosing spondylitis, uveitis and vasculitis. Although the metabolic syndrome is less prevalent in patients with IBD, they are at an increased risk for atherosclerosis and cardiovascular events. Considerable evidence supports the role of GI microbiota in the development of IBD. Recent studies have also shown a significant interaction between the metabolites of gut microbiota and the development of cardiovascular disease. Here we hypothesize that dysbiosis and/or abnormalities in the function of the intestinal microbiota promote cardiovascular disease in IBD patients, explaining the increased risk of cardiovascular events in these patients.
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Cite this article as:
Mohammad Bashashati, Hamid R. Habibi, Ali Keshavarzian, Max Schmulson and Keith A. Sharkey , Intestinal Microbiota: A Regulator of Intestinal Inflammation and Cardiac Ischemia?, Current Drug Targets 2015; 16 (3) . https://dx.doi.org/10.2174/1389450116666150120104012
DOI https://dx.doi.org/10.2174/1389450116666150120104012 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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