梓醇：一种治疗神经退行性疾病的潜在化合物

Title:Catalpol: A Potential Therapeutic for Neurodegenerative Diseases

Volume: 22 Issue: 10

Author(s): B. Jiang, R.F. Shen, J. Bi, X.S. Tian, T Hinchliffe and Y. Xia

Affiliation:

关键词: 梓醇，神经退行性疾病，神经保护，氧化应激，炎症，线粒体，核因子-κB，神经营养因子

摘要: Neurodegenerative disorders, e.g., Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by the progressive loss of neurons and subsequent cognitive decline. They are mainly found in older populations. Due to increasing life expectancies, the toll inflicted upon society by these disorders continues to become heavier and more prominent. Despite extensive research, however, the exact etiology of these disorders is still unknown, though the pathophysiological mechanisms have been attributed to oxidative, inflammatory and apoptotic injury in the brain. Moreover, there is currently no promising therapeutic agent against these neurodegenerative changes. Catalpol, an iridoid glucoside contained richly in the roots of the small flowering plant species Rehmannia glutinosa Libosch, has been shown to have antioxidation, anti-inflammation, anti-apoptosis and other neuroprotective properties and plays a role in neuroprotection against hypoxic/ischemic injury, AD and PD in both in vivo and in vitro models. It may therefore represent a potential therapeutical agent for the treatment of hypoxic/ischemic injury and neurodegenerative diseases. Based on our studies and those of others in the literature, here we comprehensively review the role of Catalpol in neuroprotection against pathological conditions, especially in neurodegenerative states and the potential mechanisms involved.

Cite this article as:

B. Jiang, R.F. Shen, J. Bi, X.S. Tian, T Hinchliffe and Y. Xia , Catalpol: A Potential Therapeutic for Neurodegenerative Diseases, Current Medicinal Chemistry 2015; 22 (10) . https://dx.doi.org/10.2174/0929867322666150114151720