P2X受体和炎症

Title:P2X Receptors and Inflammation

Volume: 22 Issue: 7

Author(s): Francesco Di Virgilio

Affiliation:

关键词: 细胞外ATP ，先天免疫， P2X4 ， P2X7 ，嘌呤受体。

摘要: Until recently, P2X receptors have not received much attention in the context of immunology and inflammation. While this is justified to a certain extent for P2X1, P2X2, P2X3, P2X5 and P2X6, which still await identification of a convincing role in the pathophysiology of immune cells, it is clearly not any more the case for P2X4 and even more so for P2X7, a molecule that has achieved the status of an essential, nonredundant, immunomodulatory receptor. In this review I will highlight the most important inflammatory responses participated by P2X receptors.

Cite this article as:

Francesco Di Virgilio , P2X Receptors and Inflammation, Current Medicinal Chemistry 2015; 22 (7) . https://dx.doi.org/10.2174/0929867322666141210155311