Abstract
Squamous cell carcinoma of the mucosal surfaces of the head and neck area exhibits a complex interaction with the host immune system that plays an important part in the evolution of the malignant process, in the resistance to different therapeutic modalities, and the ability of tumor cells to metastasize to distant organs. The recent advances in tumor immunology have transformed the field in onco-immunology from using non-specific immune-stimulant agents such as interferon and interleukins to the area of rationally targeted immunotherapy such as immune checkpoint inhibitors, which have shown promising results in early phase clinical trials.
Keywords: Checkpoint inhibitors, cytokines, HNSCC, immune system, immunotherapy, PD-1.
Graphical Abstract
Current Molecular Pharmacology
Title:Progress in Immunotherapy of Head and Neck Squamous Cell Carcinoma
Volume: 9
Author(s): Salah Almokadem
Affiliation:
Keywords: Checkpoint inhibitors, cytokines, HNSCC, immune system, immunotherapy, PD-1.
Abstract: Squamous cell carcinoma of the mucosal surfaces of the head and neck area exhibits a complex interaction with the host immune system that plays an important part in the evolution of the malignant process, in the resistance to different therapeutic modalities, and the ability of tumor cells to metastasize to distant organs. The recent advances in tumor immunology have transformed the field in onco-immunology from using non-specific immune-stimulant agents such as interferon and interleukins to the area of rationally targeted immunotherapy such as immune checkpoint inhibitors, which have shown promising results in early phase clinical trials.
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Cite this article as:
Almokadem Salah, Progress in Immunotherapy of Head and Neck Squamous Cell Carcinoma, Current Molecular Pharmacology 2016; 9 (3) . https://dx.doi.org/10.2174/1874467208666150716120658
DOI https://dx.doi.org/10.2174/1874467208666150716120658 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
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