Abstract
Diabetes is a well-known risk factor for Alzheimer`s disease (AD) development in the elderly. The molecular link between diabetes and AD is still not completely understood. Recent evidence suggests that platelet activation observed in diabetes may contribute to AD development. The present review summarizes the common molecular mechanisms involved in the pathophysiology of diabetes and AD and suggests novel therapeutic targets for prevention of the onset or slowing the progression of this disease.
Keywords: Alzheimer's disease, diabetes, platelets, vascular dementia.
Current Alzheimer Research
Title:Platelets as Potential Link Between Diabetes and Alzheimer's Disease
Volume: 11 Issue: 9
Author(s): Voahanginirina Randriamboavonjy, Kateryna Sopova, Konstantinos Stellos and Christoph Laske
Affiliation:
Keywords: Alzheimer's disease, diabetes, platelets, vascular dementia.
Abstract: Diabetes is a well-known risk factor for Alzheimer`s disease (AD) development in the elderly. The molecular link between diabetes and AD is still not completely understood. Recent evidence suggests that platelet activation observed in diabetes may contribute to AD development. The present review summarizes the common molecular mechanisms involved in the pathophysiology of diabetes and AD and suggests novel therapeutic targets for prevention of the onset or slowing the progression of this disease.
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Randriamboavonjy Voahanginirina, Sopova Kateryna, Stellos Konstantinos and Laske Christoph, Platelets as Potential Link Between Diabetes and Alzheimer's Disease, Current Alzheimer Research 2014; 11 (9) . https://dx.doi.org/10.2174/156720501109141013115258
DOI https://dx.doi.org/10.2174/156720501109141013115258 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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