摘要
糖尿病是在中老年人群中阿尔茨海默病(AD)的发展众所周知的风险因素。糖尿病和AD之间的分子联系仍然没有完全了解。最近的证据表明,在糖尿病上观察到血小板的活化可能有助于AD的发展。本综述概括了糖尿病和AD的病理生理学中的常见分子机制,并为预防发病或延缓这种疾病的发展提出新的治疗目标。
关键词: 阿尔茨海默病,糖尿病,血小板,血管性痴呆
Current Alzheimer Research
Title:Platelets as Potential Link Between Diabetes and Alzheimer's Disease
Volume: 11 Issue: 9
Author(s): Voahanginirina Randriamboavonjy, Kateryna Sopova, Konstantinos Stellos and Christoph Laske
Affiliation:
关键词: 阿尔茨海默病,糖尿病,血小板,血管性痴呆
摘要: Diabetes is a well-known risk factor for Alzheimer`s disease (AD) development in the elderly. The molecular link between diabetes and AD is still not completely understood. Recent evidence suggests that platelet activation observed in diabetes may contribute to AD development. The present review summarizes the common molecular mechanisms involved in the pathophysiology of diabetes and AD and suggests novel therapeutic targets for prevention of the onset or slowing the progression of this disease.
Export Options
About this article
Cite this article as:
Randriamboavonjy Voahanginirina, Sopova Kateryna, Stellos Konstantinos and Laske Christoph, Platelets as Potential Link Between Diabetes and Alzheimer's Disease, Current Alzheimer Research 2014; 11 (9) . https://dx.doi.org/10.2174/156720501109141013115258
DOI https://dx.doi.org/10.2174/156720501109141013115258 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Impact of the CD40-CD40L Dyad in Alzheimers Disease
CNS & Neurological Disorders - Drug Targets Renal Biopsy Research with Implications for Therapy of Glomerulonephritis
Current Drug Therapy Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets From Pharmacotherapy to Pathophysiology: Emerging Mechanisms of Apolipoprotein D in Psychiatric Disorders
Current Molecular Medicine Neuropathological Correlates of Cerebral Multimorbidity
Current Alzheimer Research Silence of the Limbs: Pharmacological Symptomatic Treatment of Intermittent Claudication
Current Vascular Pharmacology Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential
Current Pharmaceutical Design Gene Therapy for Parkinsons and Alzheimers Diseases: from the Bench to Clinical Trials
Current Pharmaceutical Design Enzymatic Activity and Protein Interactions in Alpha/Beta Hydrolase Fold Proteins: Moonlighting Versus Promiscuity
Protein & Peptide Letters Biomarker Assessment in Nutritional Modulation of Oxidative Stress-Induced Cancer Development by Lipid-Related Bioactive Molecules
Recent Patents on Anti-Cancer Drug Discovery Age-related Changes in Pharmacodynamics: Focus on Drugs Acting on Central Nervous and Cardiovascular Systems
Current Drug Metabolism Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area
Current Psychiatry Reviews Optical Sensors for Detection of Amino Acids
Current Medicinal Chemistry Hypoxic Preconditioning Ameliorates Amyloid-β Pathology and Longterm Cognitive Decline in AβPP/PS1 Transgenic Mice
Current Alzheimer Research Kinetics of In Vitro Inhibition of Acetylcholinesterase by Nineteen New Carbamates
Current Enzyme Inhibition Microglial Activation in Alzheimers Disease
Current Alzheimer Research Statins and Thrombin
Current Drug Targets - Cardiovascular & Hematological Disorders Structure Function Analysis of Serpin Super-Family: "A Computational Approach"
Protein & Peptide Letters K114 Inhibits A-beta Aggregation and Inflammation In Vitro and In Vivo in AD/Tg Mice
Current Alzheimer Research PLA2G6 Mutations and Other Rare Causes of Neurodegeneration with Brain Iron Accumulation
Current Drug Targets