摘要
糖尿病是在中老年人群中阿尔茨海默病(AD)的发展众所周知的风险因素。糖尿病和AD之间的分子联系仍然没有完全了解。最近的证据表明,在糖尿病上观察到血小板的活化可能有助于AD的发展。本综述概括了糖尿病和AD的病理生理学中的常见分子机制,并为预防发病或延缓这种疾病的发展提出新的治疗目标。
关键词: 阿尔茨海默病,糖尿病,血小板,血管性痴呆
Current Alzheimer Research
Title:Platelets as Potential Link Between Diabetes and Alzheimer's Disease
Volume: 11 Issue: 9
Author(s): Voahanginirina Randriamboavonjy, Kateryna Sopova, Konstantinos Stellos and Christoph Laske
Affiliation:
关键词: 阿尔茨海默病,糖尿病,血小板,血管性痴呆
摘要: Diabetes is a well-known risk factor for Alzheimer`s disease (AD) development in the elderly. The molecular link between diabetes and AD is still not completely understood. Recent evidence suggests that platelet activation observed in diabetes may contribute to AD development. The present review summarizes the common molecular mechanisms involved in the pathophysiology of diabetes and AD and suggests novel therapeutic targets for prevention of the onset or slowing the progression of this disease.
Export Options
About this article
Cite this article as:
Randriamboavonjy Voahanginirina, Sopova Kateryna, Stellos Konstantinos and Laske Christoph, Platelets as Potential Link Between Diabetes and Alzheimer's Disease, Current Alzheimer Research 2014; 11 (9) . https://dx.doi.org/10.2174/156720501109141013115258
DOI https://dx.doi.org/10.2174/156720501109141013115258 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Complex and Differential Glial Responses in Alzheimer´s Disease and Ageing
Current Alzheimer Research NO to Breast: When, Why and Why Not?
Current Pharmaceutical Design APP Transgenic Mouse Models and their Use in Drug Discovery to Evaluate Amyloid-β Lowering Therapeutics
CNS & Neurological Disorders - Drug Targets Inflammatory Risk Factors and Pathologies Associated with Alzheimers Disease
Current Alzheimer Research Anderson-Fabry Disease: A Multiorgan Disease
Current Pharmaceutical Design Evaluating High-Dose Rivastigmine Patch in Severe Alzheimer’s Disease: Analyses with Concomitant Memantine Usage as a Factor
Current Alzheimer Research Potential for Stem Cells Therapy in Alzheimer’s Disease: Do Neurotrophic Factors Play Critical Role?
Current Alzheimer Research Early Tau Pathology Involving the Septo-Hippocampal Pathway in a Tau Transgenic Model: Relevance to Alzheimers Disease
Current Alzheimer Research Role of Ischemic Blood-Brain Barrier on Amyloid Plaques Development in Alzheimers Disease Brain
Current Neurovascular Research A Novel Immunotherapy for Alzheimers Disease: Antibodies against the β-Secretase Cleavage Site of APP
Current Alzheimer Research Cognitive, Psychological and Psychiatric Effects of Ionizing Radiation Exposure
Current Medicinal Chemistry Optical Sensors for Detection of Amino Acids
Current Medicinal Chemistry Editorial [Hot Topic:Gamma-Secretase Inhibitors and Modulators as a Therapeutic Approach to Alzheimers disease (Guest Editor: Bruno P. Imbimbo)]
Current Topics in Medicinal Chemistry <i>In-silico</i> Studies and Biological Activity of Potential BACE-1 Inhibitors
Combinatorial Chemistry & High Throughput Screening Possible Mechanisms of Action of NSAIDs and Related Compounds that Modulate γ - Secretase Cleavage
Current Topics in Medicinal Chemistry The Molecular Genetics of Migraine: Toward the Identification of Responsible Genes
Current Genomics Drugs of Abuse and their Detection Methodologies: Contribution of Chemical Sensor
Current Organic Chemistry A Friend in Need May Not be a Friend Indeed: Role of Microglia in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Anemia and Chronic Kidney Disease: Making Sense of the Recent Trials
Reviews on Recent Clinical Trials Flavonoids in Human Health: From Structure to Biological Activity
Current Nutrition & Food Science