摘要
背景:目前研究表明吸烟和饮酒与痴呆的发生率并不一致。目的:我们对吸烟和饮酒与患有痴呆的风险性之间关系进行了评估,其中对阿尔茨海默症(AD)和血管性痴呆症(VaD)病人进行了7年随访。实验设计:根据他们的吸烟和饮酒情况,我们对2004-2011年的2959位老年人痴呆症的发生率进行了回顾性分析。样本:来自重庆市3个区的6个社区。参与者:对3170位男性随访了7年。检测方法:为了评估吸烟和饮酒与患有痴呆风险之间的联系,我们建立了Cox比例风险模型。结果:通过7年随访,我们发现目前吸烟的和每天吸烟的AD和AaD的发生几率分别高于从不吸烟的人群(P<0.01)。在平衡了年龄和其它混杂因素后,目前吸烟的与增加患AD (HR= 2.14, 95% CI 1.20-4.46) 和VaD (HR= 3.42, 95% CI 1.18-4.51) 的风险性相联系;与此同时,每日饮酒与增加患AD (HR= 2.25, 95% CI 1.43-3.97) 和VaD (HR= 3.42, 95% CI 1.18-4.51)的风险性相关。另外,同时吸烟和饮酒的人比从不吸烟和饮酒的人有明显高的患有AD (HR= 3.03, 95% CI 1.65-4.19) 和VaD (HR= 3.96, 95% CI 1.64-4.71) 的风险性;而且,与目前吸烟和每日饮酒的相比,同时吸烟和饮酒的患AD和VaD的风险性更高。结论:发现目前吸烟和每日饮酒的老年人与痴呆有明显的关联性。
关键词: 饮酒,阿尔茨海默病,吸烟,血管性痴呆
Current Alzheimer Research
Title:Association of Smoking and Alcohol Drinking with Dementia Risk Among Elderly Men in China
Volume: 11 Issue: 9
Author(s): Shiming Zhou, Rui Zhou, Tingting Zhong, Rui Li, Jun Tan and Huadong Zhou
Affiliation:
关键词: 饮酒,阿尔茨海默病,吸烟,血管性痴呆
摘要: Background: Previous studies relating smoking and alcohol drinking with the incidence of dementia have been inconsistent. Objectives: We assessed whether smoking and alcohol drinking was associated with the risk of dementia, including Alzheimer disease (AD) and vascular dementia (VaD) after seven years of follow-up. Design: We prospectively analysed the incidence of dementia from 2004 to 2011 among 2959 elderly men, according to their smoking and alcohol drinking status. Setting: six neighbourhoods from three districts mentioned in Chongqing city. Participants: A total of 3170 men were followed up annually for 7 years. Measurements: Cox proportional hazards models were established to evaluate the association between smoking, alcohol drinking and the risk of dementia. Results: The incidences of AD and VaD were higher respectively in current smoking than never smoking, daily drinking than never drinking over 7 years of follow-up (p<0.01). After adjusting for age and other potential confounders, current smoking was associated with increased risk of AD (HR= 2.14, 95% CI 1.20-4.46) and VaD (HR= 3.28, 95% CI 1.14-4.52), meanwhile, daily drinking was related to increased risk of AD (HR= 2.25, 95% CI 1.43-3.97) and VaD (HR= 3.42, 95% CI 1.18-4.51). In addition, co-smoking and drinking were related to with a significantly higher risk of AD and VaD than non-smoking and drinking (HR= 3.03, 95% CI 1.65-4.19) and VaD (HR= 3.96, 95% CI 1.64-4.71). Moreover, co-smoking and drinking had higher risk of AD and VaD compared with current smoking and daily drinking. Conclusions: Current smoking and daily drinking were found to be significantly associated with dementia in elderly men.
Export Options
About this article
Cite this article as:
Zhou Shiming, Zhou Rui, Zhong Tingting, Li Rui, Tan Jun and Zhou Huadong, Association of Smoking and Alcohol Drinking with Dementia Risk Among Elderly Men in China, Current Alzheimer Research 2014; 11 (9) . https://dx.doi.org/10.2174/1567205011666141001123356
DOI https://dx.doi.org/10.2174/1567205011666141001123356 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases
Current Medicinal Chemistry Editorial[Hot Topic:Membrane Channels as Therapeutic Targets (Executive Editor: Jean-Claude Herve)]
Current Pharmaceutical Design Towards Alzheimers Disease Vaccination
Mini-Reviews in Medicinal Chemistry Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
Current Hypertension Reviews Novel Targets for Drugs in Schizophrenia
CNS & Neurological Disorders - Drug Targets Donepezil May Reduce Insulin-Like Growth Factor-1 (IGF-1) Levels in Alzheimer’s disease
CNS & Neurological Disorders - Drug Targets PDE4D Gene in the STRK1 Region on 5q12: Susceptibility Gene for Ischemic Stroke
Current Medicinal Chemistry Cyclooxygenase-1 and -2 in the Different Stages of Alzheimers Disease Pathology
Current Pharmaceutical Design Editorial [Hot Topic New Clinical Indications of Antipsychotic Medications Guest Editors: Filippo Bogetto and Silvio Bellino]
Current Psychopharmacology Human Immunodeficiency Virus-Mononuclear Phagocyte Interactions:Emerging Avenues of Biomarker Discovery, Modes of Viral Persistence and Disease Pathogenesis
Current HIV Research Dancing as an Intervention Tool for People with Dementia: A Mini-Review Dancing and Dementia
Current Alzheimer Research Allocentric to Egocentric Spatial Switching: Impairment in aMCI and Alzheimer's Disease Patients?
Current Alzheimer Research Conformation as the Therapeutic Target for Neurodegenerative Diseases
Current Alzheimer Research Pharmacological Interventions to Attenuate Alzheimer’s Disease Progression: The Story So Far
Current Alzheimer Research Probing Cerebrovascular Alterations in Alzheimers Disease Using MRI: From Transgenic Models to Patients
Current Medical Imaging Editorial (Thematic Issue: Novel Perspectives for Parkinson’s Disease Therapy: Insights from the Latest Advances in Disease Pathophysiology, Diagnostic and Experimental Tools and Molecular Targets)
CNS & Neurological Disorders - Drug Targets The Critical Period for Neuroprotection by Estrogen Replacement Therapy and the Potential Underlying Mechanisms
Current Neuropharmacology Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis
Current Alzheimer Research Efficient Synthesis and Discovery of Schiff Bases as Potent Cholinesterase Inhibitors
Medicinal Chemistry Clinical Management of Diabetes Mellitus in the Older Adult Patient
Current Diabetes Reviews